Targeting Metabolism as a Platform for Inducing Allograft Tolerance in the Absence of Long-Term Immunosuppression

Chih Hsien Cheng, Chen Fang Lee, Byoung Chol Oh, Georg J. Furtmüller, Chirag H. Patel, Gerald Brandacher, Jonathan D. Powell

Research output: Contribution to journalArticle

Abstract

Transplant tolerance in the absence of long-term immunosuppression has been an elusive goal for solid organ transplantation. Recently, it has become clear that metabolic reprogramming plays a critical role in promoting T cell activation, differentiation, and function. Targeting metabolism can preferentially inhibit T cell effector generation while simultaneously promoting the generation of T regulatory cells. We hypothesized that costimulatory blockade with CTLA4Ig in combination with targeting T cell metabolism might provide a novel platform to promote the induction of transplant tolerance.

Original languageEnglish (US)
Article number572
JournalFrontiers in immunology
Volume11
DOIs
StatePublished - Apr 9 2020

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Keywords

  • costimulation blockade
  • immunology
  • metabolism
  • model
  • mouse
  • rejection
  • transplantation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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