Targeting Metabolic Cross Talk Between Cancer Cells and Cancer-Associated Fibroblasts

Jin G. Jung, Anne Le

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Although cancer has classically been regarded as a genetic disease of uncontrolled cell growth, the importance of the tumor microenvironment (TME) [1, 2] is continuously emphasized by the accumulating evidence that cancer growth is not simply dependent on the cancer cells themselves [3, 4] but also dependent on angiogenesis [5–8], inflammation [9, 10], and the supporting roles of cancer-associated fibroblasts (CAFs) [11–13]. After the discovery that CAFs are able to remodel the tumor matrix within the TME and provide the nutrients and chemicals to promote cancer cell growth [14], many studies have aimed to uncover the cross talk between cancer cells and CAFs. Moreover, a new paradigm in cancer metabolism shows how cancer cells act like “metabolic parasites” to take up the high-energy metabolites, such as lactate, ketone bodies, free fatty acids, and glutamine from supporting cells, including CAFs and cancer-associated adipocytes (CAAs) [15, 16]. This chapter provides an overview of the metabolic coupling between CAFs and cancer cells to further define the therapeutic options to disrupt the CAF-cancer cell interactions.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer
Pages205-214
Number of pages10
DOIs
StatePublished - 2021
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1311
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Cancer therapy
  • Cancer-associated adipocytes
  • Cancer-associated fibroblasts
  • Metabolism
  • Metabolites
  • Tumor microenvironment

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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