Targeting HIV: Past, present and future

Michèle D. Zeier, Jean B. Nachega

Research output: Contribution to journalArticlepeer-review


Since the identification of the Human Immunodeficiency Virus (HIV) as the cause of the syndrome of Acquired Immunodeficiency Syndrome (AIDS), there has been an evolution of compounds targeting the replication of the virus in an effort to delay clinical progression. In this review, we revise the mechanism of action of the different groups of drugs. We shortly revisit the older and perhaps lesser used as well as the more recently approved drugs and mention some of the compounds still under investigation.

Original languageEnglish (US)
Pages (from-to)98-114
Number of pages17
JournalInfectious Disorders - Drug Targets
Issue number2
StatePublished - 2011


  • Antiretroviral
  • HIV
  • Review
  • Targets
  • Therapy

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Microbiology (medical)


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