Targeting HIF-1 for cancer therapy

Research output: Contribution to journalReview article

Abstract

Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes that are involved in crucial aspects of cancer biology, including angiogenesis, cell survival, glucose metabolism and invasion. Intratumoral hypoxia and genetic alterations can lead to HIF-1α overexpression, which has been associated with increased patient mortality in several cancer types. In preclinical studies, inhibition of HIF-1 activity has marked effects on tumour growth. Efforts are underway to identify inhibitors of HIF-1 and to test their efficacy as anticancer therapeutics.

Original languageEnglish (US)
Pages (from-to)721-732
Number of pages12
JournalNature Reviews Cancer
Volume3
Issue number10
DOIs
StatePublished - Oct 2003

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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