Targeting glycolytic adaptations of cancer cells: From molecular mechanisms to therapeutic opportunities

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Metabolic reprogramming is one of the biochemical signatures of cancer cells. Particularly, aerobic glycolysis (i.e. the process of conversion of glucose into pyruvate followed by fermentation into lactate even in the presence of oxygen) has been of immense interest due to its impact not only on cancer cells but on the tumor microenvironment as well. Conceptual advancement in understanding the oncogenic regulation of glycolysis and multifunctional properties of glycolytic enzymes underscore the relevance and significance of targeting glycolysis in cancer cells. This chapter will discuss, in the light of recent research the intricacies of glycolytic adaptation in cancer cells, and the rationale for exploiting it for therapeutic intervention.

Original languageEnglish (US)
Title of host publicationStress Response Pathways in Cancer
Subtitle of host publicationFrom Molecular Targets to Novel Therapeutics
PublisherSpringer Netherlands
Pages331-344
Number of pages14
ISBN (Electronic)9789401794213
ISBN (Print)9789401794206
DOIs
StatePublished - Jan 1 2015

Keywords

  • ATP
  • Acidosis
  • Aerobic glycolysis
  • Antiglycolytic therapy
  • Apoptosis
  • Chemoresistance
  • Embden-Meyerhof-Parnas pathway
  • Glycolysis
  • Hypoxia
  • Metabolic reprogram
  • Metabolic stress
  • Microenvironment
  • Monocarboxylate transporters
  • Reactive oxygen species
  • Warburg effect

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Ganapathy-Kanniappan, S. (2015). Targeting glycolytic adaptations of cancer cells: From molecular mechanisms to therapeutic opportunities. In Stress Response Pathways in Cancer: From Molecular Targets to Novel Therapeutics (pp. 331-344). Springer Netherlands. https://doi.org/10.1007/978-94-017-9421-3_15