Targeting alternatively spliced sequence features for cancer diagnosis and therapeutics.

Levan Atanelov, Qiang Xu, Ramin Rad, Christopher Lee

Research output: Contribution to journalArticlepeer-review

Abstract

Alternative splicing is emerging as a major new mechanism of functional regulation in mammals, and there is increasing evidence that human cancers often involve significant changes in alternative splicing. In some cases, these changes contribute functionally to the maintenance of the transformed state and could be useful as novel targets for anticancer therapy. In other cases, they reflect changes due to tumorigenesis and could be useful for diagnostic purposes. Fundamentally, alternative splicing offers a novel opportunity to target individual subregions of a gene product that are preferentially expressed in tumors and which are not found in isoforms of the same gene found preferentially in normal tissues.

Original languageEnglish (US)
Pages (from-to)14-20
Number of pages7
JournalJournal of Gastroenterology
Volume40 Suppl 16
StatePublished - Mar 2005
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology

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