Targeted treatment of prostate cancer

Xinning Wang, Lihong Yin, Pravin Rao, Robert Stein, Kelley M. Harsch, Zhenghong Lee, Warren D.W. Heston

Research output: Contribution to journalReview article

Abstract

Over a half century ago, Charles Huggins demonstrated the response of prostate cancer to androgen deprivation therapy. Subsequently, many discoveries and evolving findings continued to support a research rationale focused on the androgen receptor (AR) as a key target for prostate cancer. More recently, preliminary trials have suggested that other targets could also be useful in the treatment of prostate cancer, and the proposed strategies for treatment have ranged from targeted toxins to immunotherapeutic agents. We provide an overview of some of these approaches, with an emphasis on those that employ prostate specific membrane antigen (PSMA) as a target.

Original languageEnglish (US)
Pages (from-to)571-579
Number of pages9
JournalJournal of cellular biochemistry
Volume102
Issue number3
DOIs
StatePublished - Oct 15 2007

Keywords

  • Prostate cancer
  • Prostate specific antigen (PSA)
  • Prostate specific membrane antigen (PSMA)

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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  • Cite this

    Wang, X., Yin, L., Rao, P., Stein, R., Harsch, K. M., Lee, Z., & Heston, W. D. W. (2007). Targeted treatment of prostate cancer. Journal of cellular biochemistry, 102(3), 571-579. https://doi.org/10.1002/jcb.21491