Targeted polymeric nanoparticles for cancer gene therapy

Jayoung Kim, David R. Wilson, Camila G. Zamboni, Jordan Green

Research output: Contribution to journalArticle

Abstract

In this article, advances in designing polymeric nanoparticles for targeted cancer gene therapy are reviewed. Characterization and evaluation of biomaterials, targeting ligands, and transcriptional elements are each discussed. Advances in biomaterials have driven improvements to nanoparticle stability and tissue targeting, conjugation of ligands to the surface of polymeric nanoparticles enable binding to specific cancer cells, and the design of transcriptional elements has enabled selective DNA expression specific to the cancer cells. Together, these features have improved the performance of polymeric nanoparticles as targeted non-viral gene delivery vectors to treat cancer. As polymeric nanoparticles can be designed to be biodegradable, non-toxic, and to have reduced immunogenicity and tumorigenicity compared to viral platforms, they have significant potential for clinical use. Results of polymeric gene therapy in clinical trials and future directions for the engineering of nanoparticle systems for targeted cancer gene therapy are also presented.

Original languageEnglish (US)
Pages (from-to)627-641
Number of pages15
JournalJournal of Drug Targeting
Volume23
Issue number7-8
DOIs
StatePublished - Sep 14 2015

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Neoplasm Genes
Genetic Therapy
Nanoparticles
Biocompatible Materials
Ligands
Neoplasms
Clinical Trials
DNA
Genes

Keywords

  • Cancer therapy
  • cell-specificity
  • gene delivery
  • nanoparticles
  • polymeric biomaterial
  • promoter
  • targeting ligands
  • tissue-specificity

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Targeted polymeric nanoparticles for cancer gene therapy. / Kim, Jayoung; Wilson, David R.; Zamboni, Camila G.; Green, Jordan.

In: Journal of Drug Targeting, Vol. 23, No. 7-8, 14.09.2015, p. 627-641.

Research output: Contribution to journalArticle

Kim, Jayoung ; Wilson, David R. ; Zamboni, Camila G. ; Green, Jordan. / Targeted polymeric nanoparticles for cancer gene therapy. In: Journal of Drug Targeting. 2015 ; Vol. 23, No. 7-8. pp. 627-641.
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