TY - JOUR
T1 - Targeted Molecular Imaging in Oncology
T2 - Focus on Radiation Therapy
AU - Nimmagadda, Sridhar
AU - Ford, Eric C.
AU - Wong, John W.
AU - Pomper, Martin G.
PY - 2008/4
Y1 - 2008/4
N2 - Anatomically based technologies (computed tomography scans, magnetic resonance imaging, and so on) are in routine use in radiotherapy for planning and assessment purposes. Even with improvements in imaging, however, radiotherapy is still limited in efficacy and toxicity in certain applications. Further advances may be provided by technologies that image the molecular activities of tumors and normal tissues. Possible uses for molecular imaging include better localization of tumor regions and early assay for the radiation response of tumors and normal tissues. Critical to the success of this approach is the identification and validation of molecular probes that are suitable in the radiotherapy context. Recent developments in molecular-imaging probes and integration of functional imaging with radiotherapy are promising. This review focuses on recent advances in molecular imaging strategies and probes that may aid in improving the efficacy of radiotherapy.
AB - Anatomically based technologies (computed tomography scans, magnetic resonance imaging, and so on) are in routine use in radiotherapy for planning and assessment purposes. Even with improvements in imaging, however, radiotherapy is still limited in efficacy and toxicity in certain applications. Further advances may be provided by technologies that image the molecular activities of tumors and normal tissues. Possible uses for molecular imaging include better localization of tumor regions and early assay for the radiation response of tumors and normal tissues. Critical to the success of this approach is the identification and validation of molecular probes that are suitable in the radiotherapy context. Recent developments in molecular-imaging probes and integration of functional imaging with radiotherapy are promising. This review focuses on recent advances in molecular imaging strategies and probes that may aid in improving the efficacy of radiotherapy.
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U2 - 10.1016/j.semradonc.2007.10.009
DO - 10.1016/j.semradonc.2007.10.009
M3 - Article
C2 - 18314068
AN - SCOPUS:39749173788
SN - 1053-4296
VL - 18
SP - 136
EP - 148
JO - Seminars in Radiation Oncology
JF - Seminars in Radiation Oncology
IS - 2
ER -