Targeted magnetic hyperthermia

Roland Stone, Thomas Willi, Yitzhak Rosen, Olin Thompson Mefford, Frank Alexis

Research output: Contribution to journalReview articlepeer-review

Abstract

Many nanotechnologies, which enable unique approaches to treat cancer, have been developed based upon non-toxic organic and inorganic materials to improve current cancer treatments. The use of inorganic materials to form magnetic nanoparticles for hyperthermia therapy is of great interest for localized treatment of cancers without effecting adjacent healthy tissue. Extensive clinical trials have begun using magnetic hyperthermia in animal models. The purpose of this article is to address different factors that affect targeting, heating and biodistribution to safely control the therapeutic efficacy of targeted magnetic hyperthermia. This method involves accumulation of magnetic nanoparticles at a tumor site and then manipulating the magnetic properties of the nanoparticles to heat the targeted tissues.

Original languageEnglish (US)
Pages (from-to)815-838
Number of pages24
JournalTherapeutic Delivery
Volume2
Issue number6
DOIs
StatePublished - Jun 1 2011
Externally publishedYes

ASJC Scopus subject areas

  • Pharmaceutical Science

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