Targeted Local Therapy for Management of Intracranial High-Grade Gliomas

Iddo Paldor, Kaisorn L. Chaichana, Henry Brem, Betty Mae Tyler

Research output: Contribution to journalArticlepeer-review

Abstract

Systemic chemotherapy of malignant brain tumors has failed to achieve sufficient drug concentrations at the neoplasm site and frequently results in severe toxicities. Therefore, the local application of several anticancer agents, oncolytic viruses and vectors for gene therapy, immune-modifying preparations, and angiogenesis inhibitors has been investigated widely. Various modes of their administration were introduced, including intratumoral injections, implantation of reservoirs or pumps, convection-enhanced delivery, and use of nanocarriers, thermoreversible gels, microchips, and drug-loaded polymers. Many of these therapeutic approaches have shown promising results in management of high-grade gliomas.

Original languageEnglish (US)
Pages (from-to)159-171
Number of pages13
JournalProgress in neurological surgery
Volume32
DOIs
StatePublished - Jan 1 2018

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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