TY - JOUR
T1 - Targeted Local Therapy for Management of Intracranial High-Grade Gliomas
AU - Paldor, Iddo
AU - Chaichana, Kaisorn L.
AU - Brem, Henry
AU - Tyler, Betty Mae
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Systemic chemotherapy of malignant brain tumors has failed to achieve sufficient drug concentrations at the neoplasm site and frequently results in severe toxicities. Therefore, the local application of several anticancer agents, oncolytic viruses and vectors for gene therapy, immune-modifying preparations, and angiogenesis inhibitors has been investigated widely. Various modes of their administration were introduced, including intratumoral injections, implantation of reservoirs or pumps, convection-enhanced delivery, and use of nanocarriers, thermoreversible gels, microchips, and drug-loaded polymers. Many of these therapeutic approaches have shown promising results in management of high-grade gliomas.
AB - Systemic chemotherapy of malignant brain tumors has failed to achieve sufficient drug concentrations at the neoplasm site and frequently results in severe toxicities. Therefore, the local application of several anticancer agents, oncolytic viruses and vectors for gene therapy, immune-modifying preparations, and angiogenesis inhibitors has been investigated widely. Various modes of their administration were introduced, including intratumoral injections, implantation of reservoirs or pumps, convection-enhanced delivery, and use of nanocarriers, thermoreversible gels, microchips, and drug-loaded polymers. Many of these therapeutic approaches have shown promising results in management of high-grade gliomas.
UR - http://www.scopus.com/inward/record.url?scp=85051078801&partnerID=8YFLogxK
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U2 - 10.1159/000469688
DO - 10.1159/000469688
M3 - Article
C2 - 29990982
AN - SCOPUS:85051078801
SN - 0079-6492
VL - 32
SP - 159
EP - 171
JO - Progress in neurological surgery
JF - Progress in neurological surgery
ER -