Targeted laryngeal photodynamic therapy with a balloon diffusing light source

Craig Grossman; Timothy Zhu; Jarod Finlay; Andrea Dimofte; Kelly Malloy; Bert O'Malley; Gregory Weinstein; Theresa M. Busch; Harry Quon

doi:10.1016/j.pdpdt.2010.06.001

Targeted laryngeal photodynamic therapy with a balloon diffusing light source

Craig Grossman, Timothy Zhu, Jarod Finlay, Andrea Dimofte, Kelly Malloy, Bert O'Malley, Gregory Weinstein, Theresa M. Busch, Harry Quon

Research output: Contribution to journal › Article › peer-review

Abstract

Photodynamic therapy (PDT) has been used for pre-malignant mucosal lesions. In an attempt to treat a patient with recurrent high-grade dysplasia of the glottic larynx, we were faced with technical challenges leading us to abandon the classic microlens fiber for a 2-cm long translucent diffusing balloon catheter to deliver photoactivating light to the targeted lesion. Real-time measurements confirmed stable photobleaching with augmentation of the prescribed light fluence secondary to light scatter in regions not in contact with the balloon diffuser. We report a potential new application of the balloon catheter that may be more suitable for anterior glottic lesions associated with minimal acute toxicity.

Original language	English (US)
Pages (from-to)	158-161
Number of pages	4
Journal	Photodiagnosis and photodynamic therapy
Volume	7
Issue number	3
DOIs	https://doi.org/10.1016/j.pdpdt.2010.06.001
State	Published - Sep 2010
Externally published	Yes

Keywords

ALA
Balloon catheter
Head and neck pre-malignant lesions
Levulan
Photodynamic therapy
Protoporphyrin IX

ASJC Scopus subject areas

Biophysics
Oncology
Dermatology
Pharmacology (medical)

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10.1016/j.pdpdt.2010.06.001

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Targeted laryngeal photodynamic therapy with a balloon diffusing light source. / Grossman, Craig; Zhu, Timothy; Finlay, Jarod; Dimofte, Andrea; Malloy, Kelly; O'Malley, Bert; Weinstein, Gregory; Busch, Theresa M.; Quon, Harry.

In: Photodiagnosis and photodynamic therapy, Vol. 7, No. 3, 09.2010, p. 158-161.

Research output: Contribution to journal › Article › peer-review

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abstract = "Photodynamic therapy (PDT) has been used for pre-malignant mucosal lesions. In an attempt to treat a patient with recurrent high-grade dysplasia of the glottic larynx, we were faced with technical challenges leading us to abandon the classic microlens fiber for a 2-cm long translucent diffusing balloon catheter to deliver photoactivating light to the targeted lesion. Real-time measurements confirmed stable photobleaching with augmentation of the prescribed light fluence secondary to light scatter in regions not in contact with the balloon diffuser. We report a potential new application of the balloon catheter that may be more suitable for anterior glottic lesions associated with minimal acute toxicity.",

keywords = "ALA, Balloon catheter, Head and neck pre-malignant lesions, Levulan, Photodynamic therapy, Protoporphyrin IX",

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AU - Finlay, Jarod

AU - Dimofte, Andrea

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AU - O'Malley, Bert

AU - Weinstein, Gregory

AU - Busch, Theresa M.

AU - Quon, Harry

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AB - Photodynamic therapy (PDT) has been used for pre-malignant mucosal lesions. In an attempt to treat a patient with recurrent high-grade dysplasia of the glottic larynx, we were faced with technical challenges leading us to abandon the classic microlens fiber for a 2-cm long translucent diffusing balloon catheter to deliver photoactivating light to the targeted lesion. Real-time measurements confirmed stable photobleaching with augmentation of the prescribed light fluence secondary to light scatter in regions not in contact with the balloon diffuser. We report a potential new application of the balloon catheter that may be more suitable for anterior glottic lesions associated with minimal acute toxicity.

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KW - Balloon catheter

KW - Head and neck pre-malignant lesions

KW - Levulan

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KW - Protoporphyrin IX

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Targeted laryngeal photodynamic therapy with a balloon diffusing light source

Abstract

Keywords

ASJC Scopus subject areas

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