Targeted laryngeal photodynamic therapy with a balloon diffusing light source

Craig Grossman, Timothy Zhu, Jarod Finlay, Andrea Dimofte, Kelly Malloy, Bert O'Malley, Gregory Weinstein, Theresa M. Busch, Harry Quon

Research output: Contribution to journalArticlepeer-review

Abstract

Photodynamic therapy (PDT) has been used for pre-malignant mucosal lesions. In an attempt to treat a patient with recurrent high-grade dysplasia of the glottic larynx, we were faced with technical challenges leading us to abandon the classic microlens fiber for a 2-cm long translucent diffusing balloon catheter to deliver photoactivating light to the targeted lesion. Real-time measurements confirmed stable photobleaching with augmentation of the prescribed light fluence secondary to light scatter in regions not in contact with the balloon diffuser. We report a potential new application of the balloon catheter that may be more suitable for anterior glottic lesions associated with minimal acute toxicity.

Original languageEnglish (US)
Pages (from-to)158-161
Number of pages4
JournalPhotodiagnosis and photodynamic therapy
Volume7
Issue number3
DOIs
StatePublished - Sep 2010
Externally publishedYes

Keywords

  • ALA
  • Balloon catheter
  • Head and neck pre-malignant lesions
  • Levulan
  • Photodynamic therapy
  • Protoporphyrin IX

ASJC Scopus subject areas

  • Biophysics
  • Oncology
  • Dermatology
  • Pharmacology (medical)

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