Targeted disruption of β1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction

Donald E. White, Natasza A. Kurpios, Dongmei Zuo, John A. Hassell, Sandra Blaess, Ulrich Mueller, William J. Muller

Research output: Contribution to journalArticle

Abstract

Despite evidence demonstrating the role of β1-integrin in the regulation of cancer cell proliferation in vitro, the importance of this cell adhesion receptor during the initiation and progression of epithelial tumors in vivo remains unclear. Here we have used the Cre/LoxP1 recombination system to disrupt β1-integrin function in the mammary epithelium of a transgenic mouse model of human breast cancer. Using this approach, we show that β1-integrin expression is critical for the initiation of mammary tumorigenesis in vivo, and for maintaining the proliferative capacity of late-stage tumor cells. These observations provide a direct demonstration that β1-integrin plays a critical role in both the initiation and maintenance of mammary tumor growth in vivo.

Original languageEnglish (US)
Pages (from-to)159-170
Number of pages12
JournalCancer Cell
Volume6
Issue number2
DOIs
StatePublished - Aug 2004
Externally publishedYes

Fingerprint

Integrins
Transgenic Mice
Breast Neoplasms
Breast
Neoplasms
Cell Adhesion
Genetic Recombination
Carcinogenesis
Epithelium
Maintenance
Cell Proliferation
Growth

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Oncology

Cite this

Targeted disruption of β1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction. / White, Donald E.; Kurpios, Natasza A.; Zuo, Dongmei; Hassell, John A.; Blaess, Sandra; Mueller, Ulrich; Muller, William J.

In: Cancer Cell, Vol. 6, No. 2, 08.2004, p. 159-170.

Research output: Contribution to journalArticle

White, Donald E. ; Kurpios, Natasza A. ; Zuo, Dongmei ; Hassell, John A. ; Blaess, Sandra ; Mueller, Ulrich ; Muller, William J. / Targeted disruption of β1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction. In: Cancer Cell. 2004 ; Vol. 6, No. 2. pp. 159-170.
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