@article{54ae91cbec4f47389828d649c0098ad6,
title = "Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche",
abstract = "Adult hypothalamic neurogenesis has recently been reported, but the cell of origin and the function of these newborn neurons are unknown. Using genetic fate mapping, we found that median eminence tanycytes generate newborn neurons. Blocking this neurogenesis altered the weight and metabolic activity of adult mice. These findings reveal a previously unreported neurogenic niche in the mammalian hypothalamus with important implications for metabolism.",
author = "Lee, {Daniel A.} and Bedont, {Joseph L.} and Thomas Pak and Hong Wang and Juan Song and Ana Miranda-Angulo and Vani Takiar and Vanessa Charubhumi and Francesca Balordi and Hirohide Takebayashi and Susan Aja and Eric Ford and Gordon Fishell and Seth Blackshaw",
note = "Funding Information: We thank J. Nathans, S. Hattar, N. Gaiano, P. Achanta, C. Montojo, D. McClellan, T. Shimogori, T. Moran, E. Newman, M. Taylor and W. Yap for comments on the manuscript. We also thank M. Bonaguidi, C. Montojo, J. Reyes, M. Armour, E. Velarde, N. Forbes-McBean, W.F. Han and the Johns Hopkins School of Medicine Microscope Facility for technical advice and assistance. This work was supported by US National Institutes of Health grant F31 NS063550 and an NSF Graduate Fellowship (to D.A.L.), a Basil O{\textquoteright}Connor Starter Scholar Award and grants from the Klingenstein Fund and NARSAD (to S.B.). S.B. is a W.M. Keck Distinguished Young Scholar in Medical Research.",
year = "2012",
month = may,
doi = "10.1038/nn.3079",
language = "English (US)",
volume = "15",
pages = "700--702",
journal = "Nature neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "5",
}