Abstract
This chapter is an attempt to organize and summarize a diverse literature concerning Tamm-Horsfall uromucoprotein. Importance of examination of urine sediment for casts and diagnostic classification of casts have been discussed. Despite a lack of understanding of its biologic function, clinicopathologic study of T-HM has implicated it as a component of a variety of disease states. It binds a number of proteins, including those on surfaces of bacteria and viruses. It inactivates enzymes of those organisms, possibly by reacting with ionic cofactors, such as divalent metals. Ionic binding of monovalent cations (e.g., Na+) and repulsion of anions, such as Cl-, suggest a role for T-HM in renal salt and water balance. The combination of T-HM with ions, including H+, and other materials that enhance gel formation may indicate an ion-exchange function. Gel (cast) formation in the lower nephron, however, may produce obstruction, which, following calcification, infection, or inflammation, could go on to produce stones, increase scarring, and augment reflux nephropathy. Pathogenetic roles in autoimmunity and disorders of mucus metabolism have also been speculated on.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 229-257 |
| Number of pages | 29 |
| Journal | Pathobiology annual |
| Volume | 11 |
| State | Published - 1981 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Tamm-Horsfall uromucoprotein and the pathogenesis of casts, reflux nephropathy, and nephritides. / Wenk, R. E.; Bhagavan, Belur; Rudert, J.
In: Pathobiology annual, Vol. 11, 1981, p. 229-257.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Tamm-Horsfall uromucoprotein and the pathogenesis of casts, reflux nephropathy, and nephritides.
AU - Wenk, R. E.
AU - Bhagavan, Belur
AU - Rudert, J.
PY - 1981
Y1 - 1981
N2 - This chapter is an attempt to organize and summarize a diverse literature concerning Tamm-Horsfall uromucoprotein. Importance of examination of urine sediment for casts and diagnostic classification of casts have been discussed. Despite a lack of understanding of its biologic function, clinicopathologic study of T-HM has implicated it as a component of a variety of disease states. It binds a number of proteins, including those on surfaces of bacteria and viruses. It inactivates enzymes of those organisms, possibly by reacting with ionic cofactors, such as divalent metals. Ionic binding of monovalent cations (e.g., Na+) and repulsion of anions, such as Cl-, suggest a role for T-HM in renal salt and water balance. The combination of T-HM with ions, including H+, and other materials that enhance gel formation may indicate an ion-exchange function. Gel (cast) formation in the lower nephron, however, may produce obstruction, which, following calcification, infection, or inflammation, could go on to produce stones, increase scarring, and augment reflux nephropathy. Pathogenetic roles in autoimmunity and disorders of mucus metabolism have also been speculated on.
AB - This chapter is an attempt to organize and summarize a diverse literature concerning Tamm-Horsfall uromucoprotein. Importance of examination of urine sediment for casts and diagnostic classification of casts have been discussed. Despite a lack of understanding of its biologic function, clinicopathologic study of T-HM has implicated it as a component of a variety of disease states. It binds a number of proteins, including those on surfaces of bacteria and viruses. It inactivates enzymes of those organisms, possibly by reacting with ionic cofactors, such as divalent metals. Ionic binding of monovalent cations (e.g., Na+) and repulsion of anions, such as Cl-, suggest a role for T-HM in renal salt and water balance. The combination of T-HM with ions, including H+, and other materials that enhance gel formation may indicate an ion-exchange function. Gel (cast) formation in the lower nephron, however, may produce obstruction, which, following calcification, infection, or inflammation, could go on to produce stones, increase scarring, and augment reflux nephropathy. Pathogenetic roles in autoimmunity and disorders of mucus metabolism have also been speculated on.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019761370&partnerID=8YFLogxK
M3 - Review article
C2 - 6173834
AN - SCOPUS:0019761370
VL - 11
SP - 229
EP - 257
JO - Pathobiology annual
JF - Pathobiology annual
SN - 0362-3025
ER -