Tamm-Horsfall uromucoprotein and the pathogenesis of casts, reflux nephropathy, and nephritides.

R. E. Wenk, Belur Bhagavan, J. Rudert

Research output: Contribution to journalReview article

Abstract

This chapter is an attempt to organize and summarize a diverse literature concerning Tamm-Horsfall uromucoprotein. Importance of examination of urine sediment for casts and diagnostic classification of casts have been discussed. Despite a lack of understanding of its biologic function, clinicopathologic study of T-HM has implicated it as a component of a variety of disease states. It binds a number of proteins, including those on surfaces of bacteria and viruses. It inactivates enzymes of those organisms, possibly by reacting with ionic cofactors, such as divalent metals. Ionic binding of monovalent cations (e.g., Na+) and repulsion of anions, such as Cl-, suggest a role for T-HM in renal salt and water balance. The combination of T-HM with ions, including H+, and other materials that enhance gel formation may indicate an ion-exchange function. Gel (cast) formation in the lower nephron, however, may produce obstruction, which, following calcification, infection, or inflammation, could go on to produce stones, increase scarring, and augment reflux nephropathy. Pathogenetic roles in autoimmunity and disorders of mucus metabolism have also been speculated on.

Original languageEnglish (US)
Pages (from-to)229-257
Number of pages29
JournalPathobiology annual
Volume11
StatePublished - 1981
Externally publishedYes

Fingerprint

Nephritis
Gels
Monovalent Cations
Ion Exchange
Nephrons
Mucus
Autoimmunity
Cicatrix
Anions
Salts
Metals
Urine
Ions
Viruses
Inflammation
Bacteria
Kidney
Water
Enzymes
Infection

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Tamm-Horsfall uromucoprotein and the pathogenesis of casts, reflux nephropathy, and nephritides. / Wenk, R. E.; Bhagavan, Belur; Rudert, J.

In: Pathobiology annual, Vol. 11, 1981, p. 229-257.

Research output: Contribution to journalReview article

@article{5d421fa73329476ea01a7e4376f8cb1f,
title = "Tamm-Horsfall uromucoprotein and the pathogenesis of casts, reflux nephropathy, and nephritides.",
abstract = "This chapter is an attempt to organize and summarize a diverse literature concerning Tamm-Horsfall uromucoprotein. Importance of examination of urine sediment for casts and diagnostic classification of casts have been discussed. Despite a lack of understanding of its biologic function, clinicopathologic study of T-HM has implicated it as a component of a variety of disease states. It binds a number of proteins, including those on surfaces of bacteria and viruses. It inactivates enzymes of those organisms, possibly by reacting with ionic cofactors, such as divalent metals. Ionic binding of monovalent cations (e.g., Na+) and repulsion of anions, such as Cl-, suggest a role for T-HM in renal salt and water balance. The combination of T-HM with ions, including H+, and other materials that enhance gel formation may indicate an ion-exchange function. Gel (cast) formation in the lower nephron, however, may produce obstruction, which, following calcification, infection, or inflammation, could go on to produce stones, increase scarring, and augment reflux nephropathy. Pathogenetic roles in autoimmunity and disorders of mucus metabolism have also been speculated on.",
author = "Wenk, {R. E.} and Belur Bhagavan and J. Rudert",
year = "1981",
language = "English (US)",
volume = "11",
pages = "229--257",
journal = "Pathobiology annual",
issn = "0362-3025",

}

TY - JOUR

T1 - Tamm-Horsfall uromucoprotein and the pathogenesis of casts, reflux nephropathy, and nephritides.

AU - Wenk, R. E.

AU - Bhagavan, Belur

AU - Rudert, J.

PY - 1981

Y1 - 1981

N2 - This chapter is an attempt to organize and summarize a diverse literature concerning Tamm-Horsfall uromucoprotein. Importance of examination of urine sediment for casts and diagnostic classification of casts have been discussed. Despite a lack of understanding of its biologic function, clinicopathologic study of T-HM has implicated it as a component of a variety of disease states. It binds a number of proteins, including those on surfaces of bacteria and viruses. It inactivates enzymes of those organisms, possibly by reacting with ionic cofactors, such as divalent metals. Ionic binding of monovalent cations (e.g., Na+) and repulsion of anions, such as Cl-, suggest a role for T-HM in renal salt and water balance. The combination of T-HM with ions, including H+, and other materials that enhance gel formation may indicate an ion-exchange function. Gel (cast) formation in the lower nephron, however, may produce obstruction, which, following calcification, infection, or inflammation, could go on to produce stones, increase scarring, and augment reflux nephropathy. Pathogenetic roles in autoimmunity and disorders of mucus metabolism have also been speculated on.

AB - This chapter is an attempt to organize and summarize a diverse literature concerning Tamm-Horsfall uromucoprotein. Importance of examination of urine sediment for casts and diagnostic classification of casts have been discussed. Despite a lack of understanding of its biologic function, clinicopathologic study of T-HM has implicated it as a component of a variety of disease states. It binds a number of proteins, including those on surfaces of bacteria and viruses. It inactivates enzymes of those organisms, possibly by reacting with ionic cofactors, such as divalent metals. Ionic binding of monovalent cations (e.g., Na+) and repulsion of anions, such as Cl-, suggest a role for T-HM in renal salt and water balance. The combination of T-HM with ions, including H+, and other materials that enhance gel formation may indicate an ion-exchange function. Gel (cast) formation in the lower nephron, however, may produce obstruction, which, following calcification, infection, or inflammation, could go on to produce stones, increase scarring, and augment reflux nephropathy. Pathogenetic roles in autoimmunity and disorders of mucus metabolism have also been speculated on.

UR - http://www.scopus.com/inward/record.url?scp=0019761370&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019761370&partnerID=8YFLogxK

M3 - Review article

C2 - 6173834

AN - SCOPUS:0019761370

VL - 11

SP - 229

EP - 257

JO - Pathobiology annual

JF - Pathobiology annual

SN - 0362-3025

ER -