TAM macrophages promote growth and metastasis within the cancer ecosystem

Jelani Zarif, Russell S. Taichman, Kenneth Pienta

Research output: Contribution to journal › Article

Abstract

Cancer continues to be the major cause of morbidity and death of more than 500,000 people in the US annually. Alternatively activated macrophages (M2 macrophages or TAMs) can facilitate tumor invasiveness and metastasis. As an invasive species in the tumor microenvironment, they provide an ideal therapeutic target.

Original languageEnglish (US)
Article numbere941734
JournalOncoImmunology
Volume3
Issue number7
DOIs
StatePublished - 2014

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Ecosystem
Macrophages
Neoplasm Metastasis
Introduced Species
Tumor Microenvironment
Growth
Cause of Death
Neoplasms
Morbidity
Therapeutics

Keywords

  • Epithelial to mesenchymal transition
  • Metastasis
  • Prostate cancer
  • Tumor associated macrophages

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

Cite this

TAM macrophages promote growth and metastasis within the cancer ecosystem. / Zarif, Jelani; Taichman, Russell S.; Pienta, Kenneth.

In: OncoImmunology, Vol. 3, No. 7, e941734, 2014.

Research output: Contribution to journal › Article

Zarif, J, Taichman, RS & Pienta, K 2014, 'TAM macrophages promote growth and metastasis within the cancer ecosystem', OncoImmunology, vol. 3, no. 7, e941734. https://doi.org/10.4161/21624011.2014.941734
Zarif J, Taichman RS, Pienta K. TAM macrophages promote growth and metastasis within the cancer ecosystem. OncoImmunology. 2014;3(7). e941734. https://doi.org/10.4161/21624011.2014.941734
Zarif, Jelani ; Taichman, Russell S. ; Pienta, Kenneth. / TAM macrophages promote growth and metastasis within the cancer ecosystem. In: OncoImmunology. 2014 ; Vol. 3, No. 7.
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