TAM macrophages promote growth and metastasis within the cancer ecosystem

Jelani C. Zarif, Russell S. Taichman, Kenneth J. Pienta

Research output: Contribution to journalArticlepeer-review

Abstract

Cancer continues to be the major cause of morbidity and death of more than 500,000 people in the US annually. Alternatively activated macrophages (M2 macrophages or TAMs) can facilitate tumor invasiveness and metastasis. As an invasive species in the tumor microenvironment, they provide an ideal therapeutic target.

Original languageEnglish (US)
Article numbere941734
JournalOncoImmunology
Volume3
Issue number7
DOIs
StatePublished - 2014

Keywords

  • Epithelial to mesenchymal transition
  • Metastasis
  • Prostate cancer
  • Tumor associated macrophages

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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