TAM macrophages promote growth and metastasis within the cancer ecosystem

Jelani C. Zarif; Russell S. Taichman; Kenneth J. Pienta

doi:10.4161/21624011.2014.941734

TAM macrophages promote growth and metastasis within the cancer ecosystem

Jelani C. Zarif, Russell S. Taichman, Kenneth J. Pienta

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Cancer continues to be the major cause of morbidity and death of more than 500,000 people in the US annually. Alternatively activated macrophages (M2 macrophages or TAMs) can facilitate tumor invasiveness and metastasis. As an invasive species in the tumor microenvironment, they provide an ideal therapeutic target.

Original language	English (US)
Article number	e941734
Journal	OncoImmunology
Volume	3
Issue number	7
DOIs	https://doi.org/10.4161/21624011.2014.941734
State	Published - 2014

Keywords

Epithelial to mesenchymal transition
Metastasis
Prostate cancer
Tumor associated macrophages

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

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title = "TAM macrophages promote growth and metastasis within the cancer ecosystem",

abstract = "Cancer continues to be the major cause of morbidity and death of more than 500,000 people in the US annually. Alternatively activated macrophages (M2 macrophages or TAMs) can facilitate tumor invasiveness and metastasis. As an invasive species in the tumor microenvironment, they provide an ideal therapeutic target.",

keywords = "Epithelial to mesenchymal transition, Metastasis, Prostate cancer, Tumor associated macrophages",

author = "Zarif, {Jelani C.} and Taichman, {Russell S.} and Pienta, {Kenneth J.}",

note = "Funding Information: This work is supported by the NCI grant nos. U54CA143803, CA163124, CA093900 and CA143055.",

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AU - Taichman, Russell S.

AU - Pienta, Kenneth J.

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KW - Metastasis

KW - Prostate cancer

KW - Tumor associated macrophages

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