TY - JOUR
T1 - Tall cell papillary thyroid cancer
T2 - Incidence and prognosis
AU - Terry, James H.
AU - John, Susan A.St
AU - Karkowski, Frederick J.
AU - Suarez, Jorge R.
AU - Yassa, Naguib H.
AU - Platica, Corneliu D.
AU - Marti, Jose R.
PY - 1994/11
Y1 - 1994/11
N2 - Background: The tall cell variant (TCV) of papillary thyroid cancer is reported to have a poor prognosis. This study examines the incidence and end result of surgical treatment of TCV. Methods: In this study, 240 thyroid cancers treated over a 23-year period at two hospital centers are reviewed. A total of 153 patients with papillary cancer were available for follow-up. All microscopic slides were re-examined. Results: Of the total 183 papillary cancers, 19 (10.4%) were TCV. The remainder were usual papillary or other papillary cancer variants. Patient age, tumor size, lymph node and soft-tissue involvement, recurrence, and death rates were evaluated. Multivariate statistical analysis disclosed that TCV histology, as well as age and tumor size, were significant predictors of recurrence. conclusion: Despite a high rate of recurrence in TCV cases over age 50 (6/9), there were no recurrent TCVs in cases under age 50 (0/8). Pathologists and surgeons must develop an increased awareness of this entity and implications for more radical treatment in the older age group.
AB - Background: The tall cell variant (TCV) of papillary thyroid cancer is reported to have a poor prognosis. This study examines the incidence and end result of surgical treatment of TCV. Methods: In this study, 240 thyroid cancers treated over a 23-year period at two hospital centers are reviewed. A total of 153 patients with papillary cancer were available for follow-up. All microscopic slides were re-examined. Results: Of the total 183 papillary cancers, 19 (10.4%) were TCV. The remainder were usual papillary or other papillary cancer variants. Patient age, tumor size, lymph node and soft-tissue involvement, recurrence, and death rates were evaluated. Multivariate statistical analysis disclosed that TCV histology, as well as age and tumor size, were significant predictors of recurrence. conclusion: Despite a high rate of recurrence in TCV cases over age 50 (6/9), there were no recurrent TCVs in cases under age 50 (0/8). Pathologists and surgeons must develop an increased awareness of this entity and implications for more radical treatment in the older age group.
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U2 - 10.1016/S0002-9610(05)80099-6
DO - 10.1016/S0002-9610(05)80099-6
M3 - Article
C2 - 7977973
AN - SCOPUS:0028032379
SN - 0002-9610
VL - 168
SP - 459
EP - 461
JO - The American Journal of Surgery
JF - The American Journal of Surgery
IS - 5
ER -