Talc Retinopathy in Primates: A Model of Ischemic Retinopathy: II. A Histopathologic Study

Norio Kaga, Mark O.M. Tso, Lee M. Jampol, Tomoichi Setogawa, Krishna Rao V. Rednam

Research output: Contribution to journalArticle

Abstract

Experimental talc retinopathy was produced in four adult rhesus monkeys by biweekly intravenous injections of talc for 3½ to ten months and was studied by retinal vascular flat preparations and by light microscopy. Talc particles were lodged in the walls of the precapillary arterioles and capillaries, producing focal occlusion of retinal and choroidal capillaries. The pericyte-endothelial cell ratio was 1:0.77 in the posterior pole and 1:0.53 in the retinal periphery. The horseradish peroxidase study showed leakage of tracer from the retinal vasculature into the extracellular interstitial space, but the barrier of the retinal pigment epithelium was intact. Microinfarcts produced small cystoid spaces in the outer plexiform layer, inner nuclear layer, and ganglion cell layer of the macula. Cytoid bodies and macrophages were scattered in the retina. No retinal or vitreal neovascularization was observed.

Original languageEnglish (US)
Pages (from-to)1644-1648
Number of pages5
JournalArchives of ophthalmology
Volume100
Issue number10
DOIs
StatePublished - Oct 1982

ASJC Scopus subject areas

  • Ophthalmology

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