Tails of RNA polymerase II

Research output: Contribution to journalReview articlepeer-review

Abstract

Eukaryotic RNA polymerase II contains two distinct structural domains: a catalytic core consisting of subunits that are homologous to other multisubunit RNA polymerases, and a unique extension of the carboxy-terminus of the largest subunit comprising tandem repeats of the seven amino acid sequence YSPTSPS. This repetitive 'tail' domain is essential for polymerase function in vivo. Although the nature of this essential function is unknown, actively transcribing RNA polymerase II is known to be multiphosphorylated on this repetitive domain.

Original languageEnglish (US)
Pages (from-to)383-387
Number of pages5
JournalTrends in biochemical sciences
Volume15
Issue number10
DOIs
StatePublished - Oct 1990

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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