Tailored strategies for radiation therapy in classical Hodgkin's lymphoma

Stephanie A Terezakis, Yvette L. Kasamon

Research output: Contribution to journalArticle

Abstract

Radiotherapeutic advances have contributed to the evolution of Hodgkin's lymphoma (HL) treatment paradigms. A reduction in radiation therapy (RT) field size and dose has the potential to significantly impact the therapeutic ratio by diminishing late toxicities while maintaining curability. Substantial progress in risk stratification has contributed to the development of tailored RT strategies which address both field design as well as dose. Technologic improvements have also enhanced the ability to adapt the RT technique to the individual patient. The refinement of the RT approach and its incorporation into current combined modality strategies in adult classical HL is the subject of ongoing investigation and is critically reviewed.

Original languageEnglish (US)
Pages (from-to)71-84
Number of pages14
JournalCritical Reviews in Oncology/Hematology
Volume84
Issue number1
DOIs
StatePublished - Oct 2012

Fingerprint

Hodgkin Disease
Radiotherapy
Therapeutics

Keywords

  • Hodgkin's lymphoma
  • Involved-field radiation therapy
  • Late effects
  • Radiation

ASJC Scopus subject areas

  • Oncology
  • Hematology
  • Geriatrics and Gerontology

Cite this

Tailored strategies for radiation therapy in classical Hodgkin's lymphoma. / Terezakis, Stephanie A; Kasamon, Yvette L.

In: Critical Reviews in Oncology/Hematology, Vol. 84, No. 1, 10.2012, p. 71-84.

Research output: Contribution to journalArticle

Terezakis, Stephanie A ; Kasamon, Yvette L. / Tailored strategies for radiation therapy in classical Hodgkin's lymphoma. In: Critical Reviews in Oncology/Hematology. 2012 ; Vol. 84, No. 1. pp. 71-84.
@article{1aa6955a48d24147946e2d85c879473f,
title = "Tailored strategies for radiation therapy in classical Hodgkin's lymphoma",
abstract = "Radiotherapeutic advances have contributed to the evolution of Hodgkin's lymphoma (HL) treatment paradigms. A reduction in radiation therapy (RT) field size and dose has the potential to significantly impact the therapeutic ratio by diminishing late toxicities while maintaining curability. Substantial progress in risk stratification has contributed to the development of tailored RT strategies which address both field design as well as dose. Technologic improvements have also enhanced the ability to adapt the RT technique to the individual patient. The refinement of the RT approach and its incorporation into current combined modality strategies in adult classical HL is the subject of ongoing investigation and is critically reviewed.",
keywords = "Hodgkin's lymphoma, Involved-field radiation therapy, Late effects, Radiation",
author = "Terezakis, {Stephanie A} and Kasamon, {Yvette L.}",
year = "2012",
month = "10",
doi = "10.1016/j.critrevonc.2012.02.006",
language = "English (US)",
volume = "84",
pages = "71--84",
journal = "Critical Reviews in Oncology/Hematology",
issn = "1040-8428",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Tailored strategies for radiation therapy in classical Hodgkin's lymphoma

AU - Terezakis, Stephanie A

AU - Kasamon, Yvette L.

PY - 2012/10

Y1 - 2012/10

N2 - Radiotherapeutic advances have contributed to the evolution of Hodgkin's lymphoma (HL) treatment paradigms. A reduction in radiation therapy (RT) field size and dose has the potential to significantly impact the therapeutic ratio by diminishing late toxicities while maintaining curability. Substantial progress in risk stratification has contributed to the development of tailored RT strategies which address both field design as well as dose. Technologic improvements have also enhanced the ability to adapt the RT technique to the individual patient. The refinement of the RT approach and its incorporation into current combined modality strategies in adult classical HL is the subject of ongoing investigation and is critically reviewed.

AB - Radiotherapeutic advances have contributed to the evolution of Hodgkin's lymphoma (HL) treatment paradigms. A reduction in radiation therapy (RT) field size and dose has the potential to significantly impact the therapeutic ratio by diminishing late toxicities while maintaining curability. Substantial progress in risk stratification has contributed to the development of tailored RT strategies which address both field design as well as dose. Technologic improvements have also enhanced the ability to adapt the RT technique to the individual patient. The refinement of the RT approach and its incorporation into current combined modality strategies in adult classical HL is the subject of ongoing investigation and is critically reviewed.

KW - Hodgkin's lymphoma

KW - Involved-field radiation therapy

KW - Late effects

KW - Radiation

UR - http://www.scopus.com/inward/record.url?scp=84866519374&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866519374&partnerID=8YFLogxK

U2 - 10.1016/j.critrevonc.2012.02.006

DO - 10.1016/j.critrevonc.2012.02.006

M3 - Article

C2 - 22463873

AN - SCOPUS:84866519374

VL - 84

SP - 71

EP - 84

JO - Critical Reviews in Oncology/Hematology

JF - Critical Reviews in Oncology/Hematology

SN - 1040-8428

IS - 1

ER -