Abstract
MALDI tissue imaging of tissues has become a promising technique for tracking biomarkers while determining their location and structural characterization. We have now developed specific targeting probes (oligonucleotides, antibodies), named Tag-Mass. This approach is based on probes modified with a photocleavable linker coupled with a tag cleaved and detected using mass spectrometry. Tag-Mass development is the key for a rapid, sensitive, and accurate approach to correlate levels of expression of different mRNA or proteins in diseases.
Original language | English (US) |
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Pages (from-to) | 2057-2067 |
Number of pages | 11 |
Journal | Journal of Proteome Research |
Volume | 6 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2007 |
Externally published | Yes |
Keywords
- MALDI
- Multiplex
- Photocleavage
- Proteome
- Specific tissue imaging
- Tag-Mass
- Transcriptome
ASJC Scopus subject areas
- Genetics
- Biotechnology
- Biochemistry