Tactile corpuscle-like bodies in gastrointestinal-type mucosa

Catuxa Celeiro-Muñoz, Thomas A. Huebner, Scott A. Robertson, Meredith E. Pittman, Aatur D. Singhi, Christina A. Arnold, Feriyl Bhaijee, Lysandra Voltaggio, Elizabeth A Montgomery

Research output: Contribution to journalArticle

Abstract

Tactile corpuscle-like bodies (TCLB) are microscopic Schwannian structures that simulate the superficial mechanoreceptors of the peripheral nervous system (Wagner-Meissner corpuscles). They have been described nearly exclusively in peripheral nerve sheath tumors, namely diffuse neurofibromas, and schwannomas but also in cellular nevi. There are rare reports of these structures in the gastrointestinal tract (predominantly the lower tract), with the presumption that they are incidental reactive neural proliferations. We compiled 9 cases showing this rare phenomenon in gastrointestinal-type mucosa in nonsyndromic patients to further characterize its features. There were 6 men and 3 women (age range, 39 to 79 y, mean 56 y) with lesions involving esophagus/gastro-esophageal junction (n=7), sigmoid colon (n=1), and gastric heterotopia of the cricopharynx (n=1). Endoscopic examination was abnormal in 6 of the 7 cases (including changes consistent with Barrett esophagus and polypoid/nodular mucosa) and normal in 1 of 7 cases for which this information was available. The histologic features were similar in all cases, with unencapsulated clusters of lamellated and concentrically arranged spindle cells in the lamina propria. The foci of TCLB ranged in size from

Original languageEnglish (US)
Pages (from-to)1668-1672
Number of pages5
JournalAmerican Journal of Surgical Pathology
Volume39
Issue number12
DOIs
StatePublished - Dec 1 2015

Fingerprint

Touch
Mechanoreceptors
Mucous Membrane
Lower Gastrointestinal Tract
Nerve Sheath Neoplasms
Neurofibroma
Barrett Esophagus
Nevus
Neurilemmoma
Peripheral Nervous System
Sigmoid Colon
Esophagus
Stomach

Keywords

  • diffuse neurofibroma
  • gastrointestinal tract nerve sheath tumors
  • tactoid bodies
  • Wagner-Meissner bodies

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery

Cite this

Celeiro-Muñoz, C., Huebner, T. A., Robertson, S. A., Pittman, M. E., Singhi, A. D., Arnold, C. A., ... Montgomery, E. A. (2015). Tactile corpuscle-like bodies in gastrointestinal-type mucosa. American Journal of Surgical Pathology, 39(12), 1668-1672. https://doi.org/10.1097/PAS.0000000000000480

Tactile corpuscle-like bodies in gastrointestinal-type mucosa. / Celeiro-Muñoz, Catuxa; Huebner, Thomas A.; Robertson, Scott A.; Pittman, Meredith E.; Singhi, Aatur D.; Arnold, Christina A.; Bhaijee, Feriyl; Voltaggio, Lysandra; Montgomery, Elizabeth A.

In: American Journal of Surgical Pathology, Vol. 39, No. 12, 01.12.2015, p. 1668-1672.

Research output: Contribution to journalArticle

Celeiro-Muñoz, C, Huebner, TA, Robertson, SA, Pittman, ME, Singhi, AD, Arnold, CA, Bhaijee, F, Voltaggio, L & Montgomery, EA 2015, 'Tactile corpuscle-like bodies in gastrointestinal-type mucosa', American Journal of Surgical Pathology, vol. 39, no. 12, pp. 1668-1672. https://doi.org/10.1097/PAS.0000000000000480
Celeiro-Muñoz C, Huebner TA, Robertson SA, Pittman ME, Singhi AD, Arnold CA et al. Tactile corpuscle-like bodies in gastrointestinal-type mucosa. American Journal of Surgical Pathology. 2015 Dec 1;39(12):1668-1672. https://doi.org/10.1097/PAS.0000000000000480
Celeiro-Muñoz, Catuxa ; Huebner, Thomas A. ; Robertson, Scott A. ; Pittman, Meredith E. ; Singhi, Aatur D. ; Arnold, Christina A. ; Bhaijee, Feriyl ; Voltaggio, Lysandra ; Montgomery, Elizabeth A. / Tactile corpuscle-like bodies in gastrointestinal-type mucosa. In: American Journal of Surgical Pathology. 2015 ; Vol. 39, No. 12. pp. 1668-1672.
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