Abstract
Tacrolimus (formerly known as FK506) is a macrolide immunosuppressant that has been used to prevent rejection of solid organ allografts. Acute hemolytic anemia is one of the side effects associated with tacrolimus therapy, and two mechanisms have been described to account for acute hemolytic anemia in patients receiving tacrolimus: drug-induced hemolysis and alloimmune hemolysis resulting from donor lymphocytes derived from the allograft (passenger lymphocyte syndrome). We report a case of a liver transplant recipient who developed fatal autoimmune hemolytic anemia while under treatment with tacrolimus for allograft rejection, and in whom postmortem examination revealed a clinically unsuspected posttransplant lymphoproliferative disorder. This case implicates autoimmune hemolytic anemia as a novel mechanism of acute hemolysis in patients treated with tacrolimus and further suggests that acute hemolytic anemia in this group of patients may herald an occult lymphoproliferative disorder.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 282-285 |
| Number of pages | 4 |
| Journal | Archives of Pathology and Laboratory Medicine |
| Volume | 120 |
| Issue number | 3 |
| State | Published - Mar 1996 |
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ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Medical Laboratory Technology
Cite this
Tacrolimus-related posttransplant lymphoproliferative disorder presenting as autoimmune hemolytic anemia. / DiGiuseppe, Joseph A.; Bastacky, Sheldon I.; Shirey, R. Sue; Silberman, Mark A.; Hutchins, Grover M.; Ness, Paul Michael.
In: Archives of Pathology and Laboratory Medicine, Vol. 120, No. 3, 03.1996, p. 282-285.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tacrolimus-related posttransplant lymphoproliferative disorder presenting as autoimmune hemolytic anemia
AU - DiGiuseppe, Joseph A.
AU - Bastacky, Sheldon I.
AU - Shirey, R. Sue
AU - Silberman, Mark A.
AU - Hutchins, Grover M.
AU - Ness, Paul Michael
PY - 1996/3
Y1 - 1996/3
N2 - Tacrolimus (formerly known as FK506) is a macrolide immunosuppressant that has been used to prevent rejection of solid organ allografts. Acute hemolytic anemia is one of the side effects associated with tacrolimus therapy, and two mechanisms have been described to account for acute hemolytic anemia in patients receiving tacrolimus: drug-induced hemolysis and alloimmune hemolysis resulting from donor lymphocytes derived from the allograft (passenger lymphocyte syndrome). We report a case of a liver transplant recipient who developed fatal autoimmune hemolytic anemia while under treatment with tacrolimus for allograft rejection, and in whom postmortem examination revealed a clinically unsuspected posttransplant lymphoproliferative disorder. This case implicates autoimmune hemolytic anemia as a novel mechanism of acute hemolysis in patients treated with tacrolimus and further suggests that acute hemolytic anemia in this group of patients may herald an occult lymphoproliferative disorder.
AB - Tacrolimus (formerly known as FK506) is a macrolide immunosuppressant that has been used to prevent rejection of solid organ allografts. Acute hemolytic anemia is one of the side effects associated with tacrolimus therapy, and two mechanisms have been described to account for acute hemolytic anemia in patients receiving tacrolimus: drug-induced hemolysis and alloimmune hemolysis resulting from donor lymphocytes derived from the allograft (passenger lymphocyte syndrome). We report a case of a liver transplant recipient who developed fatal autoimmune hemolytic anemia while under treatment with tacrolimus for allograft rejection, and in whom postmortem examination revealed a clinically unsuspected posttransplant lymphoproliferative disorder. This case implicates autoimmune hemolytic anemia as a novel mechanism of acute hemolysis in patients treated with tacrolimus and further suggests that acute hemolytic anemia in this group of patients may herald an occult lymphoproliferative disorder.
UR - http://www.scopus.com/inward/record.url?scp=0029866395&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029866395&partnerID=8YFLogxK
M3 - Article
VL - 120
SP - 282
EP - 285
JO - Archives of Pathology and Laboratory Medicine
JF - Archives of Pathology and Laboratory Medicine
SN - 0003-9985
IS - 3
ER -