Tachyphylaxis of human forearm vascular responses does not occur rapidly after exposure to isoproterenol

C. Michael Stein, Richard Nelson, Robert Deegan, Huaibing He, Tadashi Inagami, Marshall Frazer, Kamal F. Badr, Margaret Wood, Alastair J J Wood

Research output: Contribution to journalArticle

Abstract

In vitro and limited in vivo data suggest that rapid desensitization of β-adrenoceptor responses occurs after exposure to agonist. Tachyphylaxis to a β-adrenoceptor agonist would represent a potentially important mechanism for the short-term regulation of vascular tone. The effects of a 4-hour infusion of 400 ng/min intra-arterial isoproterenol on forearm blood flow and presynaptic β-adrenoceptor-mediated norepinephrine release were determined in eight healthy volunteers. Intra-arterial isoproterenol at 400 ng/min resulted in a significant increase in forearm blood flow in all eight subjects at all time points, with no evidence of tachyphylaxis. In fact, forearm blood flow after 4 hours of the isoproterenol infusion (22.8 ± 3.3 mL/100 mL per minute) was significantly greater than after 7 minutes (14.6 ± 2.8 mL/100 mL per minute), 15 minutes (15.4 ± 2.4 mL/100 mL, per minute), and 30 minutes (17.4 ± 3.0 mL/100 mL per minute) of the infusion (P

Original languageEnglish (US)
Pages (from-to)1294-1300
Number of pages7
JournalHypertension
Volume25
Issue number6
StatePublished - Jun 1995
Externally publishedYes

Keywords

  • isoproterenol
  • norepinephrine
  • receptors, adrenergic, beta
  • vasodilation

ASJC Scopus subject areas

  • Internal Medicine

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  • Cite this

    Stein, C. M., Nelson, R., Deegan, R., He, H., Inagami, T., Frazer, M., Badr, K. F., Wood, M., & Wood, A. J. J. (1995). Tachyphylaxis of human forearm vascular responses does not occur rapidly after exposure to isoproterenol. Hypertension, 25(6), 1294-1300.