Tachygastria induced by gastric electrical stimulation is mediated via α- and β-adrenergic pathway and inhibits antral motility in dogs

H. Ouyang, J. Xing, Jiande Chen

Research output: Contribution to journalArticle

Abstract

Background: It is known that tachygastria is associated with gastric hypomotility and retrograde gastric electrical stimulation (RGES) delays gastric emptying and is proposed for treating obesity. The aim was to investigate the effects and mechanisms of RGES on postprandial antral contraction in dogs. Methods: Seven dogs were implanted with a gastric cannula and three pairs of gastric serosal electrodes. Antral contractions and gastric myoelectrical activity were recorded immediately after a solid meal, with or without RGES, or with GES on the corpus, or with RGES under administration of propranolol. The stimulus was composed of long pulses with a tachygastrial frequency. Results: (i) GES at the tachygastrial frequency impaired gastric myoelectrical activity and induced tachygastria (ANOVA P <0.05). (ii) GES at the tachygastrial frequency suppressed antral contractions (ANOVA P <0.01) and the effect was stronger with retrograde stimulation than forward stimulation (P <0.05). (iii) GES-induced tachygastria was correlated with antral hypomotility (r = -0.60, P = 0.01). (iv) Propranolol and phentolamine abolished GES-induced tachygastria and antral hypomotility. Conclusions: Long-pulse RGES at a tachygastrial frequency suppresses postprandial antral contractions, which is attributed to an induction of tachygastria via the α- and β-adrenergic pathway.

Original languageEnglish (US)
Pages (from-to)846-853
Number of pages8
JournalNeurogastroenterology and Motility
Volume17
Issue number6
DOIs
StatePublished - Dec 2005
Externally publishedYes

Fingerprint

Adrenergic Agents
Electric Stimulation
Stomach
Dogs
Propranolol
Analysis of Variance
Antral
Phentolamine
Gastric Emptying
Meals
Electrodes
Obesity

Keywords

  • Antral contractions
  • Gastric electrical stimulation
  • Gastric myoelectrical activity
  • Motility
  • Tachygastria

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology
  • Neuroscience(all)

Cite this

@article{7a5bcf373722445190fb044651703b0f,
title = "Tachygastria induced by gastric electrical stimulation is mediated via α- and β-adrenergic pathway and inhibits antral motility in dogs",
abstract = "Background: It is known that tachygastria is associated with gastric hypomotility and retrograde gastric electrical stimulation (RGES) delays gastric emptying and is proposed for treating obesity. The aim was to investigate the effects and mechanisms of RGES on postprandial antral contraction in dogs. Methods: Seven dogs were implanted with a gastric cannula and three pairs of gastric serosal electrodes. Antral contractions and gastric myoelectrical activity were recorded immediately after a solid meal, with or without RGES, or with GES on the corpus, or with RGES under administration of propranolol. The stimulus was composed of long pulses with a tachygastrial frequency. Results: (i) GES at the tachygastrial frequency impaired gastric myoelectrical activity and induced tachygastria (ANOVA P <0.05). (ii) GES at the tachygastrial frequency suppressed antral contractions (ANOVA P <0.01) and the effect was stronger with retrograde stimulation than forward stimulation (P <0.05). (iii) GES-induced tachygastria was correlated with antral hypomotility (r = -0.60, P = 0.01). (iv) Propranolol and phentolamine abolished GES-induced tachygastria and antral hypomotility. Conclusions: Long-pulse RGES at a tachygastrial frequency suppresses postprandial antral contractions, which is attributed to an induction of tachygastria via the α- and β-adrenergic pathway.",
keywords = "Antral contractions, Gastric electrical stimulation, Gastric myoelectrical activity, Motility, Tachygastria",
author = "H. Ouyang and J. Xing and Jiande Chen",
year = "2005",
month = "12",
doi = "10.1111/j.1365-2982.2005.00696.x",
language = "English (US)",
volume = "17",
pages = "846--853",
journal = "Neurogastroenterology and Motility",
issn = "1350-1925",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Tachygastria induced by gastric electrical stimulation is mediated via α- and β-adrenergic pathway and inhibits antral motility in dogs

AU - Ouyang, H.

AU - Xing, J.

AU - Chen, Jiande

PY - 2005/12

Y1 - 2005/12

N2 - Background: It is known that tachygastria is associated with gastric hypomotility and retrograde gastric electrical stimulation (RGES) delays gastric emptying and is proposed for treating obesity. The aim was to investigate the effects and mechanisms of RGES on postprandial antral contraction in dogs. Methods: Seven dogs were implanted with a gastric cannula and three pairs of gastric serosal electrodes. Antral contractions and gastric myoelectrical activity were recorded immediately after a solid meal, with or without RGES, or with GES on the corpus, or with RGES under administration of propranolol. The stimulus was composed of long pulses with a tachygastrial frequency. Results: (i) GES at the tachygastrial frequency impaired gastric myoelectrical activity and induced tachygastria (ANOVA P <0.05). (ii) GES at the tachygastrial frequency suppressed antral contractions (ANOVA P <0.01) and the effect was stronger with retrograde stimulation than forward stimulation (P <0.05). (iii) GES-induced tachygastria was correlated with antral hypomotility (r = -0.60, P = 0.01). (iv) Propranolol and phentolamine abolished GES-induced tachygastria and antral hypomotility. Conclusions: Long-pulse RGES at a tachygastrial frequency suppresses postprandial antral contractions, which is attributed to an induction of tachygastria via the α- and β-adrenergic pathway.

AB - Background: It is known that tachygastria is associated with gastric hypomotility and retrograde gastric electrical stimulation (RGES) delays gastric emptying and is proposed for treating obesity. The aim was to investigate the effects and mechanisms of RGES on postprandial antral contraction in dogs. Methods: Seven dogs were implanted with a gastric cannula and three pairs of gastric serosal electrodes. Antral contractions and gastric myoelectrical activity were recorded immediately after a solid meal, with or without RGES, or with GES on the corpus, or with RGES under administration of propranolol. The stimulus was composed of long pulses with a tachygastrial frequency. Results: (i) GES at the tachygastrial frequency impaired gastric myoelectrical activity and induced tachygastria (ANOVA P <0.05). (ii) GES at the tachygastrial frequency suppressed antral contractions (ANOVA P <0.01) and the effect was stronger with retrograde stimulation than forward stimulation (P <0.05). (iii) GES-induced tachygastria was correlated with antral hypomotility (r = -0.60, P = 0.01). (iv) Propranolol and phentolamine abolished GES-induced tachygastria and antral hypomotility. Conclusions: Long-pulse RGES at a tachygastrial frequency suppresses postprandial antral contractions, which is attributed to an induction of tachygastria via the α- and β-adrenergic pathway.

KW - Antral contractions

KW - Gastric electrical stimulation

KW - Gastric myoelectrical activity

KW - Motility

KW - Tachygastria

UR - http://www.scopus.com/inward/record.url?scp=28544431850&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=28544431850&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2982.2005.00696.x

DO - 10.1111/j.1365-2982.2005.00696.x

M3 - Article

C2 - 16336500

AN - SCOPUS:28544431850

VL - 17

SP - 846

EP - 853

JO - Neurogastroenterology and Motility

JF - Neurogastroenterology and Motility

SN - 1350-1925

IS - 6

ER -