Tachyarrhythmia threshold of ischemic heart in 3-dimensional computer model

Matthew G. Fishler, Nitish V. Thakor

Research output: Contribution to journalConference article

Abstract

A three-dimensional (3-D) computer model of electrical propagation through an ischemic heart is presented. Thirty-eight slices through a real dog heart are discretized into 9532 1.5-mm-sided cubic elements to form the anatomical basis of the model. Each element can be in one of five states: absolutely refractory, three relative refractory states, and an excitable state. Propagation from an excited element to its neighbors occurs in 3-D with varying velocities, depending upon the current state of those neighbors. Ischemia in a specific region of the heart in this model is represented by a reduction in conduction velocities in that region. By varying both the number of extra-stimuli applied to the heart and the severity of the ischemia, this model simulates transitions into sustained, as well as spontaneously terminating, ventricular tachycardias and fibrillations. In addition, this model demonstrates that the threshold for sustained tachyarrhythmia decreases as the ischemia becomes more severe.

Original languageEnglish (US)
Pages (from-to)94-95
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume11 pt 1
StatePublished - Nov 1 1989
EventImages of the Twenty-First Century - Proceedings of the 11th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 1 - Seattle, WA, USA
Duration: Nov 9 1989Nov 12 1989

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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