t(6;14)(p22;q32): A new recurrent IGH@ translocation involving ID4 in B-cell precursor acute lymphoblastic leukemia (BCP-ALL)

Lisa J. Russell, Takashi Akasaka, Aneela Majid, Kei Ji Sugimoto, E. Loraine Karran, Inga Nagel, Lana Harder, Alexander Claviez, Stefan Gesk, Anthony Moorman, Fiona Ross, Helen Mazzullo, Jonathan C. Strefford, Reiner Siebert, Martin J.S. Dyer, Christine J. Harrison

Research output: Contribution to journalArticle

Abstract

Translocations involving the immunoglobulin heavy chain locus (IGH@) at chromosome band 14q32 are common in mature B-cell neoplasms, but are rare in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Here, we report the translocation, t(6;14)(p22;q32), involving IGH@ as a novel recurrent translocation in 13 BCP-ALL patients. Fluorescence in situ hybridization and long-distance inverse polymerase chain reaction (PCR) identified ID4 as the partner gene. Breakpoints were scattered over a 19kb region centromeric of ID4. Quantitative real-time PCR showed up-regulation of ID4 mRNA. All patients had deletions of CDKN2A and PAX5 located on the short arm of chromosome 9, frequently as a result of an isochromosome, i(9)(q10) (9/13, 69%). This study defines a new subgroup of BCP-ALL characterized by ID4 overexpression and CDKN2A and PAX5 deletions. Preliminary survival data suggest that this subgroup may be associated with a good response to therapy.

Original languageEnglish (US)
Pages (from-to)387-391
Number of pages5
JournalBlood
Volume111
Issue number1
DOIs
StatePublished - Jan 1 2008
Externally publishedYes

Fingerprint

B-Lymphoid Precursor Cells
Polymerase chain reaction
Chromosomes
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cells
Immunoglobulin Heavy Chains
Isochromosomes
Chromosomes, Human, Pair 9
Genes
Fluorescence
Fluorescence In Situ Hybridization
Messenger RNA
Real-Time Polymerase Chain Reaction
B-Lymphocytes
Up-Regulation
Polymerase Chain Reaction
Survival
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Immunology
  • Biochemistry
  • Hematology
  • Cell Biology

Cite this

Russell, L. J., Akasaka, T., Majid, A., Sugimoto, K. J., Karran, E. L., Nagel, I., ... Harrison, C. J. (2008). t(6;14)(p22;q32): A new recurrent IGH@ translocation involving ID4 in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Blood, 111(1), 387-391. https://doi.org/10.1182/blood-2007-07-092015

t(6;14)(p22;q32) : A new recurrent IGH@ translocation involving ID4 in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). / Russell, Lisa J.; Akasaka, Takashi; Majid, Aneela; Sugimoto, Kei Ji; Karran, E. Loraine; Nagel, Inga; Harder, Lana; Claviez, Alexander; Gesk, Stefan; Moorman, Anthony; Ross, Fiona; Mazzullo, Helen; Strefford, Jonathan C.; Siebert, Reiner; Dyer, Martin J.S.; Harrison, Christine J.

In: Blood, Vol. 111, No. 1, 01.01.2008, p. 387-391.

Research output: Contribution to journalArticle

Russell, LJ, Akasaka, T, Majid, A, Sugimoto, KJ, Karran, EL, Nagel, I, Harder, L, Claviez, A, Gesk, S, Moorman, A, Ross, F, Mazzullo, H, Strefford, JC, Siebert, R, Dyer, MJS & Harrison, CJ 2008, 't(6;14)(p22;q32): A new recurrent IGH@ translocation involving ID4 in B-cell precursor acute lymphoblastic leukemia (BCP-ALL)', Blood, vol. 111, no. 1, pp. 387-391. https://doi.org/10.1182/blood-2007-07-092015
Russell, Lisa J. ; Akasaka, Takashi ; Majid, Aneela ; Sugimoto, Kei Ji ; Karran, E. Loraine ; Nagel, Inga ; Harder, Lana ; Claviez, Alexander ; Gesk, Stefan ; Moorman, Anthony ; Ross, Fiona ; Mazzullo, Helen ; Strefford, Jonathan C. ; Siebert, Reiner ; Dyer, Martin J.S. ; Harrison, Christine J. / t(6;14)(p22;q32) : A new recurrent IGH@ translocation involving ID4 in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In: Blood. 2008 ; Vol. 111, No. 1. pp. 387-391.
@article{2cb8540775ac4dc2b246cc8761698d37,
title = "t(6;14)(p22;q32): A new recurrent IGH@ translocation involving ID4 in B-cell precursor acute lymphoblastic leukemia (BCP-ALL)",
abstract = "Translocations involving the immunoglobulin heavy chain locus (IGH@) at chromosome band 14q32 are common in mature B-cell neoplasms, but are rare in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Here, we report the translocation, t(6;14)(p22;q32), involving IGH@ as a novel recurrent translocation in 13 BCP-ALL patients. Fluorescence in situ hybridization and long-distance inverse polymerase chain reaction (PCR) identified ID4 as the partner gene. Breakpoints were scattered over a 19kb region centromeric of ID4. Quantitative real-time PCR showed up-regulation of ID4 mRNA. All patients had deletions of CDKN2A and PAX5 located on the short arm of chromosome 9, frequently as a result of an isochromosome, i(9)(q10) (9/13, 69{\%}). This study defines a new subgroup of BCP-ALL characterized by ID4 overexpression and CDKN2A and PAX5 deletions. Preliminary survival data suggest that this subgroup may be associated with a good response to therapy.",
author = "Russell, {Lisa J.} and Takashi Akasaka and Aneela Majid and Sugimoto, {Kei Ji} and Karran, {E. Loraine} and Inga Nagel and Lana Harder and Alexander Claviez and Stefan Gesk and Anthony Moorman and Fiona Ross and Helen Mazzullo and Strefford, {Jonathan C.} and Reiner Siebert and Dyer, {Martin J.S.} and Harrison, {Christine J.}",
year = "2008",
month = "1",
day = "1",
doi = "10.1182/blood-2007-07-092015",
language = "English (US)",
volume = "111",
pages = "387--391",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "1",

}

TY - JOUR

T1 - t(6;14)(p22;q32)

T2 - A new recurrent IGH@ translocation involving ID4 in B-cell precursor acute lymphoblastic leukemia (BCP-ALL)

AU - Russell, Lisa J.

AU - Akasaka, Takashi

AU - Majid, Aneela

AU - Sugimoto, Kei Ji

AU - Karran, E. Loraine

AU - Nagel, Inga

AU - Harder, Lana

AU - Claviez, Alexander

AU - Gesk, Stefan

AU - Moorman, Anthony

AU - Ross, Fiona

AU - Mazzullo, Helen

AU - Strefford, Jonathan C.

AU - Siebert, Reiner

AU - Dyer, Martin J.S.

AU - Harrison, Christine J.

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Translocations involving the immunoglobulin heavy chain locus (IGH@) at chromosome band 14q32 are common in mature B-cell neoplasms, but are rare in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Here, we report the translocation, t(6;14)(p22;q32), involving IGH@ as a novel recurrent translocation in 13 BCP-ALL patients. Fluorescence in situ hybridization and long-distance inverse polymerase chain reaction (PCR) identified ID4 as the partner gene. Breakpoints were scattered over a 19kb region centromeric of ID4. Quantitative real-time PCR showed up-regulation of ID4 mRNA. All patients had deletions of CDKN2A and PAX5 located on the short arm of chromosome 9, frequently as a result of an isochromosome, i(9)(q10) (9/13, 69%). This study defines a new subgroup of BCP-ALL characterized by ID4 overexpression and CDKN2A and PAX5 deletions. Preliminary survival data suggest that this subgroup may be associated with a good response to therapy.

AB - Translocations involving the immunoglobulin heavy chain locus (IGH@) at chromosome band 14q32 are common in mature B-cell neoplasms, but are rare in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Here, we report the translocation, t(6;14)(p22;q32), involving IGH@ as a novel recurrent translocation in 13 BCP-ALL patients. Fluorescence in situ hybridization and long-distance inverse polymerase chain reaction (PCR) identified ID4 as the partner gene. Breakpoints were scattered over a 19kb region centromeric of ID4. Quantitative real-time PCR showed up-regulation of ID4 mRNA. All patients had deletions of CDKN2A and PAX5 located on the short arm of chromosome 9, frequently as a result of an isochromosome, i(9)(q10) (9/13, 69%). This study defines a new subgroup of BCP-ALL characterized by ID4 overexpression and CDKN2A and PAX5 deletions. Preliminary survival data suggest that this subgroup may be associated with a good response to therapy.

UR - http://www.scopus.com/inward/record.url?scp=38049126095&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38049126095&partnerID=8YFLogxK

U2 - 10.1182/blood-2007-07-092015

DO - 10.1182/blood-2007-07-092015

M3 - Article

C2 - 17940204

AN - SCOPUS:38049126095

VL - 111

SP - 387

EP - 391

JO - Blood

JF - Blood

SN - 0006-4971

IS - 1

ER -