T4 Report

A roadmap for hazard monitoring and risk assessment of marine biotoxins on the basis of chemical and biological test systems

Mardas Daneshian, Luis M. Botana, Marie Yasmine Dechraoui Bottein, Gemma Buckland, Mònica Campàs, Ngaire Dennison, Robert W. Dickey, Jorge Diogène, Valérie Fessard, Thomas Hartung, Andrew Humpage, Marcel Leist, Jordi Molgó, Michael A. Quilliam, Costanza Rovida, Benjamin A. Suarez-Isla, Aurelia Tubaro, Kristina Wagner, Otmar Zoller, Daniel Dietrich

Research output: Contribution to journalArticle

Abstract

Aquatic food accounts for over 40% of global animal food products, and the potential contamination with toxins of algal origin - marine biotoxins - poses a health threat for consumers. The gold standards to assess toxins in aquatic food have traditionally been in vivo methods, i.e., the mouse as well as the rat bioassay. Besides ethical concerns, there is also a need for more reliable test methods because of low inter-species comparability, high intra-species variability, the high number of false positive and negative results as well as questionable extrapolation of quantitative risk to humans. For this reason, a transatlantic group of experts in the field of marine biotoxins was convened from academia and regulatory safety authorities to discuss future approaches to marine biotoxin testing. In this report they provide a background on the toxin classes, on their chemical characterization, the epidemiology, on risk assessment and management, as well as on their assumed mode of action. Most importantly, physiological functional assays such as in vitro bioassays and also analytical techniques, e.g., liquid chromatography coupled mass spectrometry (LC-MS), as substitutes for the rodent bioassay are reviewed. This forms the basis for recommendations on methodologies for hazard monitoring and risk assessment, establishment of causality of intoxications in human cases, a roadmap for research and development of human-relevant functional assays, as well as new approaches for a consumer directed safety concept.

Original languageEnglish (US)
Pages (from-to)487-545
Number of pages59
JournalAltex
Volume30
Issue number4
DOIs
StatePublished - 2013

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Biological Assay
Food
Safety
Risk Management
Liquid Chromatography
Causality
Rodentia
Mass Spectrometry
Epidemiology
Health
Research
In Vitro Techniques

Keywords

  • Consumer protection
  • Marine biotoxins
  • Regulatory toxicology
  • Risk assessment

ASJC Scopus subject areas

  • Medical Laboratory Technology
  • Pharmacology

Cite this

Daneshian, M., Botana, L. M., Bottein, M. Y. D., Buckland, G., Campàs, M., Dennison, N., ... Dietrich, D. (2013). T4 Report: A roadmap for hazard monitoring and risk assessment of marine biotoxins on the basis of chemical and biological test systems. Altex, 30(4), 487-545. https://doi.org/10.14573/altex.2013.4.487

T4 Report : A roadmap for hazard monitoring and risk assessment of marine biotoxins on the basis of chemical and biological test systems. / Daneshian, Mardas; Botana, Luis M.; Bottein, Marie Yasmine Dechraoui; Buckland, Gemma; Campàs, Mònica; Dennison, Ngaire; Dickey, Robert W.; Diogène, Jorge; Fessard, Valérie; Hartung, Thomas; Humpage, Andrew; Leist, Marcel; Molgó, Jordi; Quilliam, Michael A.; Rovida, Costanza; Suarez-Isla, Benjamin A.; Tubaro, Aurelia; Wagner, Kristina; Zoller, Otmar; Dietrich, Daniel.

In: Altex, Vol. 30, No. 4, 2013, p. 487-545.

Research output: Contribution to journalArticle

Daneshian, M, Botana, LM, Bottein, MYD, Buckland, G, Campàs, M, Dennison, N, Dickey, RW, Diogène, J, Fessard, V, Hartung, T, Humpage, A, Leist, M, Molgó, J, Quilliam, MA, Rovida, C, Suarez-Isla, BA, Tubaro, A, Wagner, K, Zoller, O & Dietrich, D 2013, 'T4 Report: A roadmap for hazard monitoring and risk assessment of marine biotoxins on the basis of chemical and biological test systems', Altex, vol. 30, no. 4, pp. 487-545. https://doi.org/10.14573/altex.2013.4.487
Daneshian, Mardas ; Botana, Luis M. ; Bottein, Marie Yasmine Dechraoui ; Buckland, Gemma ; Campàs, Mònica ; Dennison, Ngaire ; Dickey, Robert W. ; Diogène, Jorge ; Fessard, Valérie ; Hartung, Thomas ; Humpage, Andrew ; Leist, Marcel ; Molgó, Jordi ; Quilliam, Michael A. ; Rovida, Costanza ; Suarez-Isla, Benjamin A. ; Tubaro, Aurelia ; Wagner, Kristina ; Zoller, Otmar ; Dietrich, Daniel. / T4 Report : A roadmap for hazard monitoring and risk assessment of marine biotoxins on the basis of chemical and biological test systems. In: Altex. 2013 ; Vol. 30, No. 4. pp. 487-545.
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