t(2;14)(p13;q32): A recurring abnormality in lymphocytic leukemia. A pediatric oncology group study

Michael S. Watson, Vita J. Land, Andrew J. Carroll, Jeanette Pullen, Michael J. Borowitz, Michael P. Link, Michael Amylon, Frederick G. Behm

Research output: Contribution to journalArticlepeer-review

Abstract

Chromosome banding studies of 1,411 children with newly diagnosed acute lymphocytic leukemia (ALL) identified two patients with the t(2;14)(p13;q32) chromosome abnormality and a third patient with a complex three-way translocation involving the same breakpoints on chromosomes 2 and 14 but also involving chromosome 12 at band q11. The three cases demonstrated variability of immunophenotypes: one was a T-cell ALL, and two were early pre-B ALLs. All three patients achieved complete remissions and have remained in remission for 14-19 months.

Original languageEnglish (US)
Pages (from-to)121-124
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume58
Issue number2
DOIs
StatePublished - Feb 1992
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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