t(2;14)(p13;q32): A recurring abnormality in lymphocytic leukemia. A pediatric oncology group study

Michael S. Watson; Vita J. Land; Andrew J. Carroll; Jeanette Pullen; Michael J. Borowitz; Michael P. Link; Michael Amylon; Frederick G. Behm

doi:10.1016/0165-4608(92)90096-Q

t(2;14)(p13;q32): A recurring abnormality in lymphocytic leukemia. A pediatric oncology group study

Michael S. Watson, Vita J. Land, Andrew J. Carroll, Jeanette Pullen, Michael J. Borowitz, Michael P. Link, Michael Amylon, Frederick G. Behm

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Chromosome banding studies of 1,411 children with newly diagnosed acute lymphocytic leukemia (ALL) identified two patients with the t(2;14)(p13;q32) chromosome abnormality and a third patient with a complex three-way translocation involving the same breakpoints on chromosomes 2 and 14 but also involving chromosome 12 at band q11. The three cases demonstrated variability of immunophenotypes: one was a T-cell ALL, and two were early pre-B ALLs. All three patients achieved complete remissions and have remained in remission for 14-19 months.

Original language	English (US)
Pages (from-to)	121-124
Number of pages	4
Journal	Cancer Genetics and Cytogenetics
Volume	58
Issue number	2
DOIs	https://doi.org/10.1016/0165-4608(92)90096-Q
State	Published - Feb 1992
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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title = "t(2;14)(p13;q32): A recurring abnormality in lymphocytic leukemia. A pediatric oncology group study",

abstract = "Chromosome banding studies of 1,411 children with newly diagnosed acute lymphocytic leukemia (ALL) identified two patients with the t(2;14)(p13;q32) chromosome abnormality and a third patient with a complex three-way translocation involving the same breakpoints on chromosomes 2 and 14 but also involving chromosome 12 at band q11. The three cases demonstrated variability of immunophenotypes: one was a T-cell ALL, and two were early pre-B ALLs. All three patients achieved complete remissions and have remained in remission for 14-19 months.",

author = "Watson, {Michael S.} and Land, {Vita J.} and Carroll, {Andrew J.} and Jeanette Pullen and Borowitz, {Michael J.} and Link, {Michael P.} and Michael Amylon and Behm, {Frederick G.}",

year = "1992",

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doi = "10.1016/0165-4608(92)90096-Q",

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T2 - A recurring abnormality in lymphocytic leukemia. A pediatric oncology group study

AU - Watson, Michael S.

AU - Land, Vita J.

AU - Carroll, Andrew J.

AU - Pullen, Jeanette

AU - Borowitz, Michael J.

AU - Link, Michael P.

AU - Amylon, Michael

AU - Behm, Frederick G.

PY - 1992/2

Y1 - 1992/2

N2 - Chromosome banding studies of 1,411 children with newly diagnosed acute lymphocytic leukemia (ALL) identified two patients with the t(2;14)(p13;q32) chromosome abnormality and a third patient with a complex three-way translocation involving the same breakpoints on chromosomes 2 and 14 but also involving chromosome 12 at band q11. The three cases demonstrated variability of immunophenotypes: one was a T-cell ALL, and two were early pre-B ALLs. All three patients achieved complete remissions and have remained in remission for 14-19 months.

AB - Chromosome banding studies of 1,411 children with newly diagnosed acute lymphocytic leukemia (ALL) identified two patients with the t(2;14)(p13;q32) chromosome abnormality and a third patient with a complex three-way translocation involving the same breakpoints on chromosomes 2 and 14 but also involving chromosome 12 at band q11. The three cases demonstrated variability of immunophenotypes: one was a T-cell ALL, and two were early pre-B ALLs. All three patients achieved complete remissions and have remained in remission for 14-19 months.

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t(2;14)(p13;q32): A recurring abnormality in lymphocytic leukemia. A pediatric oncology group study

Abstract

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