T2* measurement during first-pass contrast-enhanced cardiac perfusion imaging

Peter Kellman, Anthony H. Aletras, Li Yueh Hsu, Elliot R. McVeigh, Andrew E. Arai

Research output: Contribution to journalArticle


First-pass contrast-enhanced (CE) myocardial perfusion imaging will experience T2* effects at peak concentrations of contrast agent. A reduction in the signal intensity of left ventricular (LV) blood due to T2* losses may effect estimates of the arterial input function (AIF) used for quantitative perfusion measurement. Imaging artifacts may also result from T2* losses as well as off-resonance due to the bolus susceptibility. We hypothesized that T2* losses would not be significant for measurement of the AIF in full-dose studies using a short echo time (TE = 0.6 ms). The purpose of this study was to directly measure T2* in the LV cavity during first-pass perfusion. For single-dose Gd-DTPA (0.1 mmol/kg at 5 ml/s), the LV blood pool T 2* had a mean value of 9 ms (N = 10) at peak enhancement. Distortion of the AIF due to T2* signal intensity loss will be less than 10% using TE = 0.6 ms.

Original languageEnglish (US)
Pages (from-to)1132-1134
Number of pages3
JournalMagnetic Resonance in Medicine
Issue number5
StatePublished - Nov 2006
Externally publishedYes


  • EPI
  • First-pass perfusion
  • Heart
  • MRI
  • T*

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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    Kellman, P., Aletras, A. H., Hsu, L. Y., McVeigh, E. R., & Arai, A. E. (2006). T2* measurement during first-pass contrast-enhanced cardiac perfusion imaging. Magnetic Resonance in Medicine, 56(5), 1132-1134. https://doi.org/10.1002/mrm.21061