T1ρ MRI of Alzheimer's disease

Arijitt Borthakur, Matthew Sochor, Christos Davatzikos, John Q. Trojanowski, Christopher M. Clark

Research output: Contribution to journalArticlepeer-review

Abstract

Alzheimer's disease (AD) is the most common form of dementia in the elderly. Classic symptoms of the disease include memory loss and confusion associated with the hallmark neuro-pathologic lesions of neurofibrillary tangles (NFT) and senile plaques (SP) and their sequelae, gray matter atrophy. Volumetric assessment methods measure tissue atrophy, which typically follows early biochemical changes. An alternate MRI contrast mechanism to visualize the early pathological changes is T (or "T-1-rho"), the spin lattice relaxation time constant in the rotating frame, which determines the decay of the transverse magnetization in the presence of a "spin-lock" radio-frequency field. Macromolecular changes (in plaques and tangles) that accompany early AD are expected to alter bulk water T relaxation times. In this work, we measure T MRI on patients with clinically diagnosed AD, MCI and in age-matched cognitively normal control subjects in order to compare T values with changes in brain volume in the same regions of the brain and demonstrate that T can potentially constitute an important biomarker of AD.

Original languageEnglish (US)
Pages (from-to)1199-1205
Number of pages7
JournalNeuroImage
Volume41
Issue number4
DOIs
StatePublished - Jul 15 2008
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Spin-lock imaging
  • T1rho

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

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