t(14;19)(q32;q13): A Recurrent Translocation in B-Cell Precursor Acute Lymphoblastic Leukemia

Hazel M. Robinson, Kerry E. Taylor, G. Reza Jalali, Kan Luk Cheung, Christine J. Harrison, Anthony V. Moorman

Research output: Contribution to journalArticle

Abstract

The recurrent t(14;19)(q32;q13) translocation associated with chronic B-cell lymphoproliferative disorders, such as atypical chronic lymphocytic leukemia, results in the juxtaposition of the IGH@ and BCL3 genes and subsequent overexpression of BCL3. We report six patients with B-cell precursor acute lymphoblastic leukemia who have a cytogenetically identical translocation with different breakpoints at the molecular level. Fluorescence in situ hybridization with locus-specific probes confirmed the involvement of the IGH@ gene but showed that the breakpoint on 19q13 lay outside the region documented in t(14;19)(q32;q13)-positive chronic lymphocytic leukemia. This newly described translocation constitutes a distinct cytogenetic subgroup that is confined to older children and younger adults with B-cell precursor acute lymphoblastic leukemia.

Original languageEnglish (US)
Pages (from-to)88-92
Number of pages5
JournalGenes Chromosomes and Cancer
Volume39
Issue number1
DOIs
StatePublished - Jan 1 2004
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

Fingerprint Dive into the research topics of 't(14;19)(q32;q13): A Recurrent Translocation in B-Cell Precursor Acute Lymphoblastic Leukemia'. Together they form a unique fingerprint.

  • Cite this