t(12;17)(p13;q21) in early pre-B acute lymphoid leukemia

R. A. Krance, S. C. Raimondi, R. Dubowy, J. Estrada, M. Borowitz, F. Behm, V. J. Land, J. Pullen, A. J. Carroll

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Abstract

Structural rearrangements involving the short arm of chromosome 12 occur in 10% of cases of childhood acute lymphoid leukemia. The translocation t(12;17)(p13;q21), an uncommon 12p abnormality, was identified in five of 2620 cases (0.2%) successfully karyotyped by the Pediatric Oncology Group or St Jude Children's Research Hospital. All five cases were classified as early pre-B; however, CD10 (common acute lymphoblastic leukemia antigen) was expressed at lower levels than other markers of B-cell lineage. Two cases also expressed the myeloid-associated antigen CD33. Leukemic cells were pseudodiploid in four cases, with an extra chromosome 21 in the fifth case. All of these patients achieved complete remission. Two relapsed during subsequent therapy, and three remain in continuous remission for ≥ 20 months.

Original languageEnglish (US)
Pages (from-to)251-255
Number of pages5
JournalLeukemia
Volume6
Issue number4
StatePublished - Apr 1992

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ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Krance, R. A., Raimondi, S. C., Dubowy, R., Estrada, J., Borowitz, M., Behm, F., Land, V. J., Pullen, J., & Carroll, A. J. (1992). t(12;17)(p13;q21) in early pre-B acute lymphoid leukemia. Leukemia, 6(4), 251-255.