t(11;18)(q21;q21) is a recurrent chromosome abnormality in small lymphocytic lymphoma

Constance A. Griffin, Barbara A. Zehnbauer, Richard Ambinder, William E. Beschorner, Risa Mann

Research output: Contribution to journalArticle

Abstract

We have identified two cases of previously untreated, small lymphocytic lymphoma with extranodal involvement, which had a reciprocal translocation, t(11;18)(q21;q21), as the sole cytogenetic abnormality. These two cases are remarkably similar to two previously reported cases carrying this translocation with regard to clinical features, cytogenetic abnormality, histologic subtype, and immunophenotype. Molecular genetic analysis of these two cases revealed clonal gene rearrangement of the IGH locus but only germline configuration of the BCL2 oncogene at 18q21 when probes and conditions that usually identify BCL2 rearrangement in lymphomas were used. Lymphomas bearing an (11;18) rearrangement appear to make up a phenotypically identifiable subgroup. Identification of the genes at the translocation breakpoints will be important.

Original languageEnglish (US)
Pages (from-to)153-157
Number of pages5
JournalGenes, Chromosomes and Cancer
Volume4
Issue number2
DOIs
StatePublished - Mar 1992

    Fingerprint

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

Cite this