TY - JOUR
T1 - T1 maps in upper abdomen
T2 - comparison of Look-Locker and B1-corrected variable-flip-angle (VFA) methods
AU - Wang, Zhaoqi
AU - Chu, Funing
AU - Bai, Bingmei
AU - Han, Shuai
AU - Zhang, Hongkai
AU - Yan, Xu
AU - Zhang, Shouning
AU - Dong, Yafeng
AU - Jiang, Lina
AU - Zhao, Yan
AU - Kamel, Ihab R.
AU - Li, Hailiang
AU - Qu, Jinrong
N1 - Funding Information:
The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article. This study has received funding by the Projects of the General Programs of the National Natural Science Foundation of China (No. 81972802), Natural Science Foundation of Henan Province (No. 182300410355), Henan Province Medical Science and Technology Research Program Provincial Department to jointly build key projects (No. SBGJ202002021), Special funding of the Henan Health Science and Technology Innovation Talent Project (No. YXKC2020011), Henan Province focuses on research and development and promotion (No. 212102310133). The protocol was approved by Henan Cancer Hospital Review Board. All the authors have followed the applicable ethical standards to maintain the research integrity without any duplication, fraud or plagiarism issues.
Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Nature Singapore Pte Ltd.
PY - 2023/3
Y1 - 2023/3
N2 - Purpose: T1 mapping has been recognized as a promising tool for quantitative measurements of various tissues that may assist in accurate and tissue specific diagnosis. The purpose of this study was to compare the T1 values of two whole-liver T1 mapping methods, free-breathing Look-Locker and breath-hold B1-corrected variable-flip-angle (VFA) in diagnosing liver cirrhosis, and compare the T1 relaxation time of various upper abdominal organs using two methods. Methods: Non-enhanced T1 mapping with whole-liver coverage was performed on 85 prospectively enrolled suspicious liver tumor patients. Multiple abdominal MRI sequences were obtained. Image quality was assessed by scoring image artifacts on 5-point scale. T1 relaxation time for each organ was recorded. Statistical significance analyzed using Paired t test. Results: T1 maps of Look-Locker method showed fewer artifacts, with score 5 in all cases compared to 36% in VFA method. There was no significant difference between cirrhotic and non-cirrhotic livers of either left or right lobe in both methods. T1 relaxation time was significantly lower (p < 0.0001) in Look-Locker than VFA method in both lobes of liver, spleen, pancreas, left kidney, right kidney, kidney cortex and medulla, erector spinae and rectus abdominis. No significant difference was found between left and right lobe of liver in both methods. T1 relaxation time of both methods was significantly lower in kidney cortex (p < 0.0001) than medulla on both left and right kidneys. Conclusions: The choice of Look-Locker or B1-corrected VFA-based T1 mapping may affect T1 values of organs in upper abdomen. Look-Locker showed better image quality and less motion artifacts than B1-corrected VFA method.
AB - Purpose: T1 mapping has been recognized as a promising tool for quantitative measurements of various tissues that may assist in accurate and tissue specific diagnosis. The purpose of this study was to compare the T1 values of two whole-liver T1 mapping methods, free-breathing Look-Locker and breath-hold B1-corrected variable-flip-angle (VFA) in diagnosing liver cirrhosis, and compare the T1 relaxation time of various upper abdominal organs using two methods. Methods: Non-enhanced T1 mapping with whole-liver coverage was performed on 85 prospectively enrolled suspicious liver tumor patients. Multiple abdominal MRI sequences were obtained. Image quality was assessed by scoring image artifacts on 5-point scale. T1 relaxation time for each organ was recorded. Statistical significance analyzed using Paired t test. Results: T1 maps of Look-Locker method showed fewer artifacts, with score 5 in all cases compared to 36% in VFA method. There was no significant difference between cirrhotic and non-cirrhotic livers of either left or right lobe in both methods. T1 relaxation time was significantly lower (p < 0.0001) in Look-Locker than VFA method in both lobes of liver, spleen, pancreas, left kidney, right kidney, kidney cortex and medulla, erector spinae and rectus abdominis. No significant difference was found between left and right lobe of liver in both methods. T1 relaxation time of both methods was significantly lower in kidney cortex (p < 0.0001) than medulla on both left and right kidneys. Conclusions: The choice of Look-Locker or B1-corrected VFA-based T1 mapping may affect T1 values of organs in upper abdomen. Look-Locker showed better image quality and less motion artifacts than B1-corrected VFA method.
KW - B1-corrected VFA
KW - Liver
KW - Look-locker
KW - MR relaxometry
KW - Magnetic resonance imaging
KW - T1 mapping
UR - http://www.scopus.com/inward/record.url?scp=85146158748&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85146158748&partnerID=8YFLogxK
U2 - 10.1007/s42058-022-00114-5
DO - 10.1007/s42058-022-00114-5
M3 - Article
AN - SCOPUS:85146158748
SN - 2520-8985
VL - 6
SP - 41
EP - 46
JO - Chinese Journal of Academic Radiology
JF - Chinese Journal of Academic Radiology
IS - 1
ER -