T1 mapping of the myocardium

Intra-individual assessment of the effect of field strength, cardiac cycle and variation by myocardial region

Nadine Kawel, Marcelo Nacif, Anna Zavodni, Jacquin Jones, Songtao Liu, Christopher T. Sibley, David A. Bluemke

Research output: Contribution to journalArticle

Abstract

Background: Myocardial T1 relaxation time (T1 time) and extracellular volume fraction (ECV) are altered in the presence of myocardial fibrosis. The purpose of this study was to evaluate acquisition factors that may result in variation of measured T1 time and ECV including magnetic field strength, cardiac phase and myocardial region. Methods: 31 study subjects were enrolled and underwent one cardiovascular MR exam at 1.5 T and two exams at 3 T, each on separate days. A Modified Look-Locker Inversion Recovery (MOLLI) sequence was acquired before and 5, 10, 12, 20, 25 and 30 min after administration of 0.15 mmol/kg gadopentetate dimeglumine (Gd-DTPA; Magnevist) at 1.5 T (exam 1). For exam 2, MOLLI sequences were acquired at 3 T both during diastole and systole, before and after administration of Gd-DTPA (0.15 mmol/kg Magnevist). Exam 3 was identical to exam 2 except gadobenate dimeglumine was administered (Gd-BOPTA; 0.1 mmol/kg Multihance). T1 times were measured in myocardium and blood. ECV was calculated by (δR1 myocardium/δR1 blood) * (1-hematocrit). Results: Before gadolinium, T1 times of myocardium and blood were significantly greater at 3 T versus 1.5 T (28% and 31% greater, respectively, p

Original languageEnglish (US)
Article number27
JournalJournal of Cardiovascular Magnetic Resonance
Volume14
Issue number1
DOIs
StatePublished - 2012
Externally publishedYes

Fingerprint

Gadolinium DTPA
Myocardium
Sequence Inversion
Diastole
Systole
Gadolinium
Magnetic Fields
Hematocrit
Fibrosis
gadobenic acid

Keywords

  • ECV
  • Extracellular volume fraction
  • Field strength
  • Modified Look-Locker inversion recovery
  • T1 mapping

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Family Practice
  • Medicine(all)

Cite this

T1 mapping of the myocardium : Intra-individual assessment of the effect of field strength, cardiac cycle and variation by myocardial region. / Kawel, Nadine; Nacif, Marcelo; Zavodni, Anna; Jones, Jacquin; Liu, Songtao; Sibley, Christopher T.; Bluemke, David A.

In: Journal of Cardiovascular Magnetic Resonance, Vol. 14, No. 1, 27, 2012.

Research output: Contribution to journalArticle

Kawel, Nadine ; Nacif, Marcelo ; Zavodni, Anna ; Jones, Jacquin ; Liu, Songtao ; Sibley, Christopher T. ; Bluemke, David A. / T1 mapping of the myocardium : Intra-individual assessment of the effect of field strength, cardiac cycle and variation by myocardial region. In: Journal of Cardiovascular Magnetic Resonance. 2012 ; Vol. 14, No. 1.
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