T-type calcium channels regulate cortical plasticity in-vivo NR-D-08-7049

Victor N. Uebele, Cindy E. Nuss, Vincent P. Santarelli, Susan L. Garson, James C. Barrow, Shaun R. Stauffer, Kenneth S. Koblan, John J. Renger, Sara Aton, Julie Seibt, Michelle Dumoulin, Sushil K. Jha, Tammi Coleman, Marcos G. Frank

Research output: Contribution to journalArticlepeer-review

Abstract

T-type voltage-dependent calcium channels may play an important role in synaptic plasticity, but lack of specific antagonists has hampered investigation into this possible function. We investigated the role of the T-type channel in a canonical model of in-vivo cortical plasticity triggered by monocular deprivation. We identified a compound (TTA-11) with subnanomolar potency in standard voltage clamp assays and high selectivity for the T-type channel. When infused intracortically, TTA-11 reduced cortical plasticity triggered by monocular deprivation while preserving normal visual response properties. These results show that the T-type calcium channel plays a central role in cortical plasticity.

Original languageEnglish (US)
Pages (from-to)257-262
Number of pages6
JournalNeuroreport
Volume20
Issue number3
DOIs
StatePublished - Feb 18 2009
Externally publishedYes

Keywords

  • Cav3.3
  • Cavt
  • Kir2.3
  • LVA
  • Monocular deprivation
  • Ocular dominance
  • Synaptic remodeling
  • Voltage-gated

ASJC Scopus subject areas

  • Neuroscience(all)

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