TY - JOUR
T1 - t 4 workshop report
AU - Kleensang, Andre
AU - Maertens, Alexandra
AU - Rosenberg, Michael
AU - Fitzpatrick, Suzanne
AU - Lamb, Justin
AU - Auerbach, Scott
AU - Brennan, Richard
AU - Crofton, Kevin M.
AU - Gordon, Ben
AU - Fornace, Albert J.
AU - Gaido, Kevin
AU - Gerhold, David
AU - Haw, Robin
AU - Henney, Adriano
AU - Ma'Ayan, Avi
AU - McBride, Mary
AU - Monti, Stefano
AU - Ochs, Michael F.
AU - Pandey, Akhilesh
AU - Sharan, Roded
AU - Stierum, Rob
AU - Tugendreich, Stuart
AU - Willett, Catherine
AU - Wittwehr, Clemens
AU - Xia, Jianguo
AU - Patton, Geoffrey W.
AU - Arvidson, Kirk
AU - Bouhifd, Mounir
AU - Hogberg, Helena T.
AU - Luechtefeld, Thomas
AU - Smirnova, Lena
AU - Zhao, Liang
AU - Adeleye, Yeyejide
AU - Kanehisa, Minoru
AU - Carmichael, Paul
AU - Andersen, Melvin E.
AU - Hartung, Thomas
PY - 2014
Y1 - 2014
N2 - Despite wide-spread consensus on the need to transform toxicology and risk assessment in order to keep pace with technological and computational changes that have revolutionized the life sciences, there remains much work to be done to achieve the vision of toxicology based on a mechanistic foundation. A workshop was organized to explore one key aspect of this transformation - the development of Pathways of Toxicity (PoT) as a key tool for hazard identification based on systems biology. Several issues were discussed in depth in the workshop: The first was the challenge of formally defining the concept of a PoT as distinct from, but complementary to, other toxicological pathway concepts such as mode of action (MoA). The workshop came up with a preliminary definition of PoT as "A molecular definition of cellular processes shown to mediate adverse outcomes of toxicants". It is further recognized that normal physiological pathways exist that maintain homeostasis and these, sufficiently perturbed, can become PoT. Second, the workshop sought to define the adequate public and commercial resources for PoT information, including data, visualization, analyses, tools, and use-cases, as well as the kinds of efforts that will be necessary to enable the creation of such a resource. Third, the workshop explored ways in which systems biology approaches could inform pathway annotation, and which resources are needed and available that can provide relevant PoT information to the diverse user communities.
AB - Despite wide-spread consensus on the need to transform toxicology and risk assessment in order to keep pace with technological and computational changes that have revolutionized the life sciences, there remains much work to be done to achieve the vision of toxicology based on a mechanistic foundation. A workshop was organized to explore one key aspect of this transformation - the development of Pathways of Toxicity (PoT) as a key tool for hazard identification based on systems biology. Several issues were discussed in depth in the workshop: The first was the challenge of formally defining the concept of a PoT as distinct from, but complementary to, other toxicological pathway concepts such as mode of action (MoA). The workshop came up with a preliminary definition of PoT as "A molecular definition of cellular processes shown to mediate adverse outcomes of toxicants". It is further recognized that normal physiological pathways exist that maintain homeostasis and these, sufficiently perturbed, can become PoT. Second, the workshop sought to define the adequate public and commercial resources for PoT information, including data, visualization, analyses, tools, and use-cases, as well as the kinds of efforts that will be necessary to enable the creation of such a resource. Third, the workshop explored ways in which systems biology approaches could inform pathway annotation, and which resources are needed and available that can provide relevant PoT information to the diverse user communities.
KW - Adverse outcome pathways
KW - Human toxome
KW - In vitro toxicology
KW - Pathways of toxicity
KW - Systems toxicology
UR - http://www.scopus.com/inward/record.url?scp=84893141038&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84893141038&partnerID=8YFLogxK
U2 - 10.14573/altex.1309261
DO - 10.14573/altex.1309261
M3 - Article
C2 - 24127042
AN - SCOPUS:84893141038
VL - 31
SP - 53
EP - 61
JO - ALTEX : Alternativen zu Tierexperimenten
JF - ALTEX : Alternativen zu Tierexperimenten
SN - 1868-596X
IS - 1
ER -