T Lymphocytes in Acute Kidney Injury and Repair

Somayeh Gharaie Fathabad; Johanna T. Kurzhagen; Mohanraj Sadasivam; Sanjeev Noel; Errol Bush; Abdel R.A. Hamad; Hamid Rabb

doi:10.1016/j.semnephrol.2020.01.003

T Lymphocytes in Acute Kidney Injury and Repair

Somayeh Gharaie Fathabad, Johanna T. Kurzhagen, Mohanraj Sadasivam, Sanjeev Noel, Errol Bush, Abdel R.A. Hamad, Hamid Rabb

School of Medicine

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Summary: Innate and adaptive immune systems participate in the pathogenesis of acute kidney injury (AKI). Considerable data from different research teams have shown the importance of T lymphocytes in the pathophysiology of AKI and, more recently, prevention and repair. T cells can generate or resolve inflammation by secreting specific cytokines and growth factors as well as interact with other immune and stromal cells to induce kidney injury or promote tissue repair. There also are emerging data on the role of T cells in the progression of AKI to chronic kidney disease and organ cross-talk in AKI. These data set the stage for immunomodulatory therapies for AKI. This review focuses on the major populations of T lymphocytes and their roles as mediators for AKI and repair.

Original language	English (US)
Pages (from-to)	114-125
Number of pages	12
Journal	Seminars in Nephrology
Volume	40
Issue number	2
DOIs	https://doi.org/10.1016/j.semnephrol.2020.01.003
State	Published - Mar 2020

Keywords

Acute kidney injury
T cells
immune system
ischemia reperfusion
repair

ASJC Scopus subject areas

Nephrology

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10.1016/j.semnephrol.2020.01.003

Cite this

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title = "T Lymphocytes in Acute Kidney Injury and Repair",

abstract = "Summary: Innate and adaptive immune systems participate in the pathogenesis of acute kidney injury (AKI). Considerable data from different research teams have shown the importance of T lymphocytes in the pathophysiology of AKI and, more recently, prevention and repair. T cells can generate or resolve inflammation by secreting specific cytokines and growth factors as well as interact with other immune and stromal cells to induce kidney injury or promote tissue repair. There also are emerging data on the role of T cells in the progression of AKI to chronic kidney disease and organ cross-talk in AKI. These data set the stage for immunomodulatory therapies for AKI. This review focuses on the major populations of T lymphocytes and their roles as mediators for AKI and repair.",

keywords = "Acute kidney injury, T cells, immune system, ischemia reperfusion, repair",

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T1 - T Lymphocytes in Acute Kidney Injury and Repair

AU - Gharaie Fathabad, Somayeh

AU - Kurzhagen, Johanna T.

AU - Sadasivam, Mohanraj

AU - Noel, Sanjeev

AU - Bush, Errol

AU - Hamad, Abdel R.A.

AU - Rabb, Hamid

PY - 2020/3

Y1 - 2020/3

N2 - Summary: Innate and adaptive immune systems participate in the pathogenesis of acute kidney injury (AKI). Considerable data from different research teams have shown the importance of T lymphocytes in the pathophysiology of AKI and, more recently, prevention and repair. T cells can generate or resolve inflammation by secreting specific cytokines and growth factors as well as interact with other immune and stromal cells to induce kidney injury or promote tissue repair. There also are emerging data on the role of T cells in the progression of AKI to chronic kidney disease and organ cross-talk in AKI. These data set the stage for immunomodulatory therapies for AKI. This review focuses on the major populations of T lymphocytes and their roles as mediators for AKI and repair.

AB - Summary: Innate and adaptive immune systems participate in the pathogenesis of acute kidney injury (AKI). Considerable data from different research teams have shown the importance of T lymphocytes in the pathophysiology of AKI and, more recently, prevention and repair. T cells can generate or resolve inflammation by secreting specific cytokines and growth factors as well as interact with other immune and stromal cells to induce kidney injury or promote tissue repair. There also are emerging data on the role of T cells in the progression of AKI to chronic kidney disease and organ cross-talk in AKI. These data set the stage for immunomodulatory therapies for AKI. This review focuses on the major populations of T lymphocytes and their roles as mediators for AKI and repair.

KW - Acute kidney injury

KW - T cells

KW - immune system

KW - ischemia reperfusion

KW - repair

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T Lymphocytes in Acute Kidney Injury and Repair

Abstract

Keywords

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