T lymphocytes and acute kidney injury: Update

M. N. Martina, S. Noel, S. Bandapalle, A. R.A. Hamad, H. Rabb

Research output: Contribution to journalArticlepeer-review


The immune system is among the key pathogenic factors in acute kidney injury (AKI). Various immune cells, including dendritic cells, natural killer T cells, T and B lymphocytes, neutrophils and macrophages are involved. Conventional CD4+ lymphocytes are well established to participate in early injury, and CD4+CD25+FoxP3 regulatory T cells are protective and can accelerate repair. A newly identified kidney T cell receptor + CD4-CD8- (double-negative) T cell has complex functions, including potentially anti-inflammatory roles in AKI. In this mini review, we summarize the data on the role of lymphocytes in AKI and set the stage for further mechanistic studies as well as interventions to improve outcomes.

Original languageEnglish (US)
Pages (from-to)51-55
Number of pages5
JournalNephron - Clinical Practice
Issue number1-4
StatePublished - Apr 16 2014


  • Acute kidney injury
  • Double-negative cells
  • Lymphocytes
  • Regulatory T cells

ASJC Scopus subject areas

  • Nephrology


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