T lymphocytes and acute kidney injury: Update

M. N. Martina, Sanjeev Noel, S. Bandapalle, Abdel R Hamad, Hamid Rabb

Research output: Contribution to journalArticle

Abstract

The immune system is among the key pathogenic factors in acute kidney injury (AKI). Various immune cells, including dendritic cells, natural killer T cells, T and B lymphocytes, neutrophils and macrophages are involved. Conventional CD4+ lymphocytes are well established to participate in early injury, and CD4+CD25+FoxP3 regulatory T cells are protective and can accelerate repair. A newly identified kidney T cell receptor + CD4-CD8- (double-negative) T cell has complex functions, including potentially anti-inflammatory roles in AKI. In this mini review, we summarize the data on the role of lymphocytes in AKI and set the stage for further mechanistic studies as well as interventions to improve outcomes.

Original languageEnglish (US)
Pages (from-to)51-55
Number of pages5
JournalNephron - Clinical Practice
Volume127
Issue number1-4
DOIs
StatePublished - Apr 16 2014

Fingerprint

Acute Kidney Injury
T-Lymphocytes
Lymphocytes
Natural Killer T-Cells
Regulatory T-Lymphocytes
T-Cell Antigen Receptor
Dendritic Cells
Immune System
Neutrophils
B-Lymphocytes
Anti-Inflammatory Agents
Macrophages
Kidney
Wounds and Injuries

Keywords

  • Acute kidney injury
  • Double-negative cells
  • Lymphocytes
  • Regulatory T cells

ASJC Scopus subject areas

  • Nephrology

Cite this

T lymphocytes and acute kidney injury : Update. / Martina, M. N.; Noel, Sanjeev; Bandapalle, S.; Hamad, Abdel R; Rabb, Hamid.

In: Nephron - Clinical Practice, Vol. 127, No. 1-4, 16.04.2014, p. 51-55.

Research output: Contribution to journalArticle

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