T-lymphocyte recognition of a portion of myelin basic protein encoded by an exon expressed during myelination

Rhonda R. Voskuhl, Dale E. McFarlin, Roger Stone, Henry F. McFarland

Research output: Contribution to journalArticle

Abstract

The major isoform of myelin basic protein (MBP) in the healthy adult central nervous system is the 18.5-kDa protein which is produced by mRNA derived from exons 1, 3, 4, 5, 6 and 7 of the MBP gene. Since isoforms containing exon 2-encoded protein (X2MBP) are expressed during myelin formation, we examined T cell ractivity specific for X2MBP in a disease characterized by remyelination subsequent to demyelination, multiple sclerosis (MS). T cell lines specific for X2MBP were derived from three MS patients as well as one healthy control. This suggests that candidate autoantigens in demyelinating/remyelinating diseases should include not only the major isoforms of myelin proteins, but also isoforms expressed aberrantly during a disease process since they too may be the target of a T cell-mediated autoimmune process.

Original languageEnglish (US)
Pages (from-to)187-191
Number of pages5
JournalJournal of Neuroimmunology
Volume42
Issue number2
DOIs
StatePublished - 1993
Externally publishedYes

Keywords

  • Multiple sclerosis
  • Myelin basic protein
  • T cell

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

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