| Original language | English (US) |
|---|---|
| Pages (from-to) | 3789-3793 |
| Number of pages | 5 |
| Journal | Biochemical Pharmacology |
| Volume | 36 |
| Issue number | 22 |
| DOIs | |
| State | Published - Nov 15 1987 |
ASJC Scopus subject areas
- Biochemistry
- Pharmacology
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In: Biochemical Pharmacology, Vol. 36, No. 22, 15.11.1987, p. 3789-3793.
Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - T-lymphocyte inhibition by cyclosporine. Potential mechanisms of action
AU - Colombani, Paul M.
AU - Hess, Allan D.
N1 - Funding Information: In a variety of animal models, CsA facilitates the induction of specific transplantation tolerance. This state of tolerance appears to be a process specific for the initial tolerance-producing antigen, since third party antigens in the form of subsequent transplants are promptly rejected [2,3]. This state of unreactivity also appears to be a dynamic, true tolerance, since withdrawal of CsA does not appear to influence graft retention in a number of animal models [4]. In humans, CsA has been used primarily in solid organ transplantation, with immediate success. CsA combined with low dose steroid administration has become the immunosuppressive regimen of choice in most transplant centers. The immediate marked improvement in clinical cardiac and liver transplantation with CsA use has removed these procedures from the realm of experimental surgery to that of accepted procedures for end-stage cardiac and liver disease. Subsequently, the clinical use of CsA has been expanded to prevent graft-versus-host disease following bone marrow transplantation for leukemia. Investigational use of CsA has also begun for the treatment of a wide variety of presumed immune disorders, including rhematoid arthritis, pri- * Supported in part by USPHS Grants CA15396 and AI20990 and American Cancer Society Grants IM442 and IM398. Dr. Hess is a scholar of the Leukemia Society of America. t Reprint address: Paul M. Colombani, M.D., Division of Pediatric Surgery, The Johns Hopkins Hospital, 600 North Broadway, Baltimore, MD 21205.
PY - 1987/11/15
Y1 - 1987/11/15
UR - http://www.scopus.com/inward/record.url?scp=0023656924&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023656924&partnerID=8YFLogxK
U2 - 10.1016/0006-2952(87)90438-2
DO - 10.1016/0006-2952(87)90438-2
M3 - Article
C2 - 3318839
AN - SCOPUS:0023656924
SN - 0006-2952
VL - 36
SP - 3789
EP - 3793
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
IS - 22
ER -