T helper 1 (TH1) functional phenotype of human myelin basic protein-specific t lymphocytes

Rhonda R. Voskuhl, Roland Martin, Cheryl Bergman, Mira Dalal, Nancy H. Ruddle, Henry F. Mcfarland

Research output: Contribution to journalArticlepeer-review

Abstract

Multiple sclerosis (MS) is widely accepted as an autoimmune disease with myelin basic protein (MBP) a candidate autoantigen. In the current report, human T cell lines specific for an immunodominant region of MBP were shown to have a functional phenotype similar to T helper 1 (Th1) inflammatory cells of the mouse on the basis of their antigen-specific cytotoxic activity and production of interferon-gamma and lymphotoxin/tumor necrosis factor-alpha, but not interleukin-4. In experimental allergic encephalo-myelitis (EAE), a proposed animal model for MS, MBP-specific T cell lines which mediate disease are of the Th1 subtype. Thus, MBP-specific T cells in humans exist which are phenotypically similar to MBP-specific encephalitogenic T cells in murine EAE.

Original languageEnglish (US)
Pages (from-to)137-143
Number of pages7
JournalAutoimmunity
Volume15
Issue number2
DOIs
StatePublished - 1993
Externally publishedYes

Keywords

  • Cytotoxic T lymphocyte
  • Interferon-gamma
  • Lymphotoxin
  • Multiple sclerosis
  • Myelin basic protein
  • T helper 1 lymphocyte

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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