T cells from patients with Parkinson's disease recognize α-synuclein peptides

David Sulzer, Roy N. Alcalay, Francesca Garretti, Lucien Cote, Ellen Kanter, Julian Agin-Liebes, Christopher Liong, Curtis McMurtrey, William H. Hildebrand, Xiaobo Mao, Valina L. Dawson, Ted M. Dawson, Carla Oseroff, John Pham, John Sidney, Myles B. Dillon, Chelsea Carpenter, Daniela Weiskopf, Elizabeth Phillips, Simon MallalBjoern Peters, April Frazier, Cecilia S. Lindestam Arlehamn, Alessandro Sette

Research output: Contribution to journalArticlepeer-review

Abstract

Genetic studies have shown the association of Parkinson's disease with alleles of the major histocompatibility complex. Here we show that a defined set of peptides that are derived from α-synuclein, a protein aggregated in Parkinson's disease, act as antigenic epitopes displayed by these alleles and drive helper and cytotoxic T cell responses in patients with Parkinson's disease. These responses may explain the association of Parkinson's disease with specific major histocompatibility complex alleles.

Original languageEnglish (US)
Pages (from-to)656-661
Number of pages6
JournalNature
Volume546
Issue number7660
DOIs
StatePublished - Jun 29 2017

ASJC Scopus subject areas

  • General

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