T cells from patients with Parkinson's disease recognize α-synuclein peptides

David Sulzer, Roy N. Alcalay, Francesca Garretti, Lucien Cote, Ellen Kanter, Julian Agin-Liebes, Christopher Liong, Curtis McMurtrey, William H. Hildebrand, Xiaobo Mao, Valina Dawson, Ted M Dawson, Carla Oseroff, John Pham, John Sidney, Myles B. Dillon, Chelsea Carpenter, Daniela Weiskopf, Elizabeth Phillips, Simon MallalBjoern Peters, April Frazier, Cecilia S. Lindestam Arlehamn, Alessandro Sette

Research output: Contribution to journalArticle

Abstract

Genetic studies have shown the association of Parkinson's disease with alleles of the major histocompatibility complex. Here we show that a defined set of peptides that are derived from α-synuclein, a protein aggregated in Parkinson's disease, act as antigenic epitopes displayed by these alleles and drive helper and cytotoxic T cell responses in patients with Parkinson's disease. These responses may explain the association of Parkinson's disease with specific major histocompatibility complex alleles.

Original languageEnglish (US)
Pages (from-to)656-661
Number of pages6
JournalNature
Volume546
Issue number7660
DOIs
StatePublished - Jun 29 2017

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ASJC Scopus subject areas

  • Medicine(all)
  • General

Cite this

Sulzer, D., Alcalay, R. N., Garretti, F., Cote, L., Kanter, E., Agin-Liebes, J., Liong, C., McMurtrey, C., Hildebrand, W. H., Mao, X., Dawson, V., Dawson, T. M., Oseroff, C., Pham, J., Sidney, J., Dillon, M. B., Carpenter, C., Weiskopf, D., Phillips, E., ... Sette, A. (2017). T cells from patients with Parkinson's disease recognize α-synuclein peptides. Nature, 546(7660), 656-661. https://doi.org/10.1038/nature22815