T cells from patients with Parkinson's disease recognize α-synuclein peptides

David Sulzer; Roy N. Alcalay; Francesca Garretti; Lucien Cote; Ellen Kanter; Julian Agin-Liebes; Christopher Liong; Curtis McMurtrey; William H. Hildebrand; Xiaobo Mao; Valina L. Dawson; Ted M. Dawson; Carla Oseroff; John Pham; John Sidney; Myles B. Dillon; Chelsea Carpenter; Daniela Weiskopf; Elizabeth Phillips; Simon Mallal; Bjoern Peters; April Frazier; Cecilia S. Lindestam Arlehamn; Alessandro Sette

doi:10.1038/nature22815

T cells from patients with Parkinson's disease recognize α-synuclein peptides

David Sulzer, Roy N. Alcalay, Francesca Garretti, Lucien Cote, Ellen Kanter, Julian Agin-Liebes, Christopher Liong, Curtis McMurtrey, William H. Hildebrand, Xiaobo Mao, Valina L. Dawson, Ted M. Dawson, Carla Oseroff, John Pham, John Sidney, Myles B. Dillon, Chelsea Carpenter, Daniela Weiskopf, Elizabeth Phillips, Simon MallalBjoern Peters, April Frazier, Cecilia S. Lindestam Arlehamn, Alessandro Sette

School of Medicine

Research output: Contribution to journal › Article › peer-review

268 Scopus citations

Abstract

Genetic studies have shown the association of Parkinson's disease with alleles of the major histocompatibility complex. Here we show that a defined set of peptides that are derived from α-synuclein, a protein aggregated in Parkinson's disease, act as antigenic epitopes displayed by these alleles and drive helper and cytotoxic T cell responses in patients with Parkinson's disease. These responses may explain the association of Parkinson's disease with specific major histocompatibility complex alleles.

Original language	English (US)
Pages (from-to)	656-661
Number of pages	6
Journal	Nature
Volume	546
Issue number	7660
DOIs	https://doi.org/10.1038/nature22815
State	Published - Jun 29 2017

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Sulzer, D., Alcalay, R. N., Garretti, F., Cote, L., Kanter, E., Agin-Liebes, J., Liong, C., McMurtrey, C., Hildebrand, W. H., Mao, X., Dawson, V. L., Dawson, T. M., Oseroff, C., Pham, J., Sidney, J., Dillon, M. B., Carpenter, C., Weiskopf, D., Phillips, E., ... Sette, A. (2017). T cells from patients with Parkinson's disease recognize α-synuclein peptides. Nature, 546(7660), 656-661. https://doi.org/10.1038/nature22815

Sulzer, D, Alcalay, RN, Garretti, F, Cote, L, Kanter, E, Agin-Liebes, J, Liong, C, McMurtrey, C, Hildebrand, WH, Mao, X , Dawson, VL , Dawson, TM, Oseroff, C, Pham, J, Sidney, J, Dillon, MB, Carpenter, C, Weiskopf, D, Phillips, E, Mallal, S, Peters, B, Frazier, A, Lindestam Arlehamn, CS & Sette, A 2017, 'T cells from patients with Parkinson's disease recognize α-synuclein peptides', Nature, vol. 546, no. 7660, pp. 656-661. https://doi.org/10.1038/nature22815

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abstract = "Genetic studies have shown the association of Parkinson's disease with alleles of the major histocompatibility complex. Here we show that a defined set of peptides that are derived from α-synuclein, a protein aggregated in Parkinson's disease, act as antigenic epitopes displayed by these alleles and drive helper and cytotoxic T cell responses in patients with Parkinson's disease. These responses may explain the association of Parkinson's disease with specific major histocompatibility complex alleles.",

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AU - Sulzer, David

AU - Alcalay, Roy N.

AU - Garretti, Francesca

AU - Cote, Lucien

AU - Kanter, Ellen

AU - Agin-Liebes, Julian

AU - Liong, Christopher

AU - McMurtrey, Curtis

AU - Hildebrand, William H.

AU - Mao, Xiaobo

AU - Dawson, Valina L.

AU - Dawson, Ted M.

AU - Oseroff, Carla

AU - Pham, John

AU - Sidney, John

AU - Dillon, Myles B.

AU - Carpenter, Chelsea

AU - Weiskopf, Daniela

AU - Phillips, Elizabeth

AU - Mallal, Simon

AU - Peters, Bjoern

AU - Frazier, April

AU - Lindestam Arlehamn, Cecilia S.

AU - Sette, Alessandro

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T cells from patients with Parkinson's disease recognize α-synuclein peptides

Abstract

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