T cells as mediators of protective immunity against liver stages of Plasmodium

Moriya Tsuji, Fidel Zavala

Research output: Contribution to journalReview article

Abstract

T cells from different subsets play a major role in protective immunity against pre-erythrocytic stages of malaria parasites. Exposure of humans and animals to malaria sporozoites induces (αβ CD8+ and CD4+ T cells specific for antigens expressed in pre-erythrocytic stages of Plasmodium. These T cells inhibit parasite development in the liver, and immunization with subunit vaccines expressing the respective antigenic moieties confers protection against sporozoite challenge. γδ and natural killer T cells can also play a role in protective immunity. Recent studies with mice transgenic for the αβ T-cell receptor have revealed the existence of complex mechanisms regulating the induction and development of these responses.

Original languageEnglish (US)
Pages (from-to)88-93
Number of pages6
JournalTrends in parasitology
Volume19
Issue number2
DOIs
StatePublished - Feb 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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