T cells as mediators of protective immunity against liver stages of Plasmodium

Moriya Tsuji, Fidel P Zavala

Research output: Contribution to journalArticle

Abstract

T cells from different subsets play a major role in protective immunity against pre-erythrocytic stages of malaria parasites. Exposure of humans and animals to malaria sporozoites induces (αβ CD8+ and CD4+ T cells specific for antigens expressed in pre-erythrocytic stages of Plasmodium. These T cells inhibit parasite development in the liver, and immunization with subunit vaccines expressing the respective antigenic moieties confers protection against sporozoite challenge. γδ and natural killer T cells can also play a role in protective immunity. Recent studies with mice transgenic for the αβ T-cell receptor have revealed the existence of complex mechanisms regulating the induction and development of these responses.

Original languageEnglish (US)
Pages (from-to)88-93
Number of pages6
JournalTrends in Parasitology
Volume19
Issue number2
DOIs
StatePublished - Feb 1 2003
Externally publishedYes

Fingerprint

Sporozoites
Plasmodium
Malaria
Immunity
Parasites
T-Lymphocytes
Subunit Vaccines
Natural Killer T-Cells
Liver
T-Lymphocyte Subsets
T-Cell Antigen Receptor
Transgenic Mice
Immunization
Antigens

ASJC Scopus subject areas

  • Infectious Diseases
  • Parasitology

Cite this

T cells as mediators of protective immunity against liver stages of Plasmodium. / Tsuji, Moriya; Zavala, Fidel P.

In: Trends in Parasitology, Vol. 19, No. 2, 01.02.2003, p. 88-93.

Research output: Contribution to journalArticle

@article{c60e847612d748ad85965e1e10dddaa1,
title = "T cells as mediators of protective immunity against liver stages of Plasmodium",
abstract = "T cells from different subsets play a major role in protective immunity against pre-erythrocytic stages of malaria parasites. Exposure of humans and animals to malaria sporozoites induces (αβ CD8+ and CD4+ T cells specific for antigens expressed in pre-erythrocytic stages of Plasmodium. These T cells inhibit parasite development in the liver, and immunization with subunit vaccines expressing the respective antigenic moieties confers protection against sporozoite challenge. γδ and natural killer T cells can also play a role in protective immunity. Recent studies with mice transgenic for the αβ T-cell receptor have revealed the existence of complex mechanisms regulating the induction and development of these responses.",
author = "Moriya Tsuji and Zavala, {Fidel P}",
year = "2003",
month = "2",
day = "1",
doi = "10.1016/S1471-4922(02)00053-3",
language = "English (US)",
volume = "19",
pages = "88--93",
journal = "Trends in Parasitology",
issn = "1471-4922",
publisher = "Elsevier Limited",
number = "2",

}

TY - JOUR

T1 - T cells as mediators of protective immunity against liver stages of Plasmodium

AU - Tsuji, Moriya

AU - Zavala, Fidel P

PY - 2003/2/1

Y1 - 2003/2/1

N2 - T cells from different subsets play a major role in protective immunity against pre-erythrocytic stages of malaria parasites. Exposure of humans and animals to malaria sporozoites induces (αβ CD8+ and CD4+ T cells specific for antigens expressed in pre-erythrocytic stages of Plasmodium. These T cells inhibit parasite development in the liver, and immunization with subunit vaccines expressing the respective antigenic moieties confers protection against sporozoite challenge. γδ and natural killer T cells can also play a role in protective immunity. Recent studies with mice transgenic for the αβ T-cell receptor have revealed the existence of complex mechanisms regulating the induction and development of these responses.

AB - T cells from different subsets play a major role in protective immunity against pre-erythrocytic stages of malaria parasites. Exposure of humans and animals to malaria sporozoites induces (αβ CD8+ and CD4+ T cells specific for antigens expressed in pre-erythrocytic stages of Plasmodium. These T cells inhibit parasite development in the liver, and immunization with subunit vaccines expressing the respective antigenic moieties confers protection against sporozoite challenge. γδ and natural killer T cells can also play a role in protective immunity. Recent studies with mice transgenic for the αβ T-cell receptor have revealed the existence of complex mechanisms regulating the induction and development of these responses.

UR - http://www.scopus.com/inward/record.url?scp=0037312371&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037312371&partnerID=8YFLogxK

U2 - 10.1016/S1471-4922(02)00053-3

DO - 10.1016/S1471-4922(02)00053-3

M3 - Article

VL - 19

SP - 88

EP - 93

JO - Trends in Parasitology

JF - Trends in Parasitology

SN - 1471-4922

IS - 2

ER -