T cells as mediators of protective immunity against liver stages of Plasmodium

Moriya Tsuji; Fidel Zavala

doi:10.1016/S1471-4922(02)00053-3

T cells as mediators of protective immunity against liver stages of Plasmodium

Moriya Tsuji, Fidel Zavala

Research output: Contribution to journal › Review article › peer-review

68 Scopus citations

Abstract

T cells from different subsets play a major role in protective immunity against pre-erythrocytic stages of malaria parasites. Exposure of humans and animals to malaria sporozoites induces (αβ CD8⁺ and CD4⁺ T cells specific for antigens expressed in pre-erythrocytic stages of Plasmodium. These T cells inhibit parasite development in the liver, and immunization with subunit vaccines expressing the respective antigenic moieties confers protection against sporozoite challenge. γδ and natural killer T cells can also play a role in protective immunity. Recent studies with mice transgenic for the αβ T-cell receptor have revealed the existence of complex mechanisms regulating the induction and development of these responses.

Original language	English (US)
Pages (from-to)	88-93
Number of pages	6
Journal	Trends in parasitology
Volume	19
Issue number	2
DOIs	https://doi.org/10.1016/S1471-4922(02)00053-3
State	Published - Feb 1 2003
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Infectious Diseases

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10.1016/S1471-4922(02)00053-3

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title = "T cells as mediators of protective immunity against liver stages of Plasmodium",

abstract = "T cells from different subsets play a major role in protective immunity against pre-erythrocytic stages of malaria parasites. Exposure of humans and animals to malaria sporozoites induces (αβ CD8+ and CD4+ T cells specific for antigens expressed in pre-erythrocytic stages of Plasmodium. These T cells inhibit parasite development in the liver, and immunization with subunit vaccines expressing the respective antigenic moieties confers protection against sporozoite challenge. γδ and natural killer T cells can also play a role in protective immunity. Recent studies with mice transgenic for the αβ T-cell receptor have revealed the existence of complex mechanisms regulating the induction and development of these responses.",

author = "Moriya Tsuji and Fidel Zavala",

note = "Funding Information: We thank Photini Sinnis and Julius Hafalla for critically reviewing this manuscript. Research is supported by NIH grants AI44375 (F.Z.) and AI47840 (M.T.).",

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T1 - T cells as mediators of protective immunity against liver stages of Plasmodium

AU - Tsuji, Moriya

AU - Zavala, Fidel

N1 - Funding Information: We thank Photini Sinnis and Julius Hafalla for critically reviewing this manuscript. Research is supported by NIH grants AI44375 (F.Z.) and AI47840 (M.T.).

PY - 2003/2/1

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N2 - T cells from different subsets play a major role in protective immunity against pre-erythrocytic stages of malaria parasites. Exposure of humans and animals to malaria sporozoites induces (αβ CD8+ and CD4+ T cells specific for antigens expressed in pre-erythrocytic stages of Plasmodium. These T cells inhibit parasite development in the liver, and immunization with subunit vaccines expressing the respective antigenic moieties confers protection against sporozoite challenge. γδ and natural killer T cells can also play a role in protective immunity. Recent studies with mice transgenic for the αβ T-cell receptor have revealed the existence of complex mechanisms regulating the induction and development of these responses.

AB - T cells from different subsets play a major role in protective immunity against pre-erythrocytic stages of malaria parasites. Exposure of humans and animals to malaria sporozoites induces (αβ CD8+ and CD4+ T cells specific for antigens expressed in pre-erythrocytic stages of Plasmodium. These T cells inhibit parasite development in the liver, and immunization with subunit vaccines expressing the respective antigenic moieties confers protection against sporozoite challenge. γδ and natural killer T cells can also play a role in protective immunity. Recent studies with mice transgenic for the αβ T-cell receptor have revealed the existence of complex mechanisms regulating the induction and development of these responses.

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T cells as mediators of protective immunity against liver stages of Plasmodium

Abstract

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