T-cell vaccination reduces simian immunodeficiency virus levels in semen

James B. Whitney; Corinne Luedemann; Peter Hraber; Srinivas S. Rao; John R. Mascola; Gary J. Nabel; Norman L. Letvin

doi:10.1128/JVI.01202-09

T-cell vaccination reduces simian immunodeficiency virus levels in semen

James B. Whitney, Corinne Luedemann, Peter Hraber, Srinivas S. Rao, John R. Mascola, Gary J. Nabel, Norman L. Letvin

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Recent findings suggest that most sexual transmission of human immunodeficiency virus type 1 (HIV-1) occurs during the acute phase of infection when viral replication is most intense. Here, we show that vaccineelicited cellular immune responses can significantly reduce simian immunodeficiency virus levels in the semen during the period of primary infection in monkeys. A vaccine that decreases the quantity of HIV-1 in the semen of males during primary infection might decrease HIV-1 transmission in human populations and therefore affect the spread of AIDS.

Original language	English (US)
Pages (from-to)	10840-10843
Number of pages	4
Journal	Journal of virology
Volume	83
Issue number	20
DOIs	https://doi.org/10.1128/JVI.01202-09
State	Published - Oct 2009
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

Access to Document

10.1128/JVI.01202-09

Cite this

@article{1d20c8cf95444ccfadacda9d0c04c718,

title = "T-cell vaccination reduces simian immunodeficiency virus levels in semen",

abstract = "Recent findings suggest that most sexual transmission of human immunodeficiency virus type 1 (HIV-1) occurs during the acute phase of infection when viral replication is most intense. Here, we show that vaccineelicited cellular immune responses can significantly reduce simian immunodeficiency virus levels in the semen during the period of primary infection in monkeys. A vaccine that decreases the quantity of HIV-1 in the semen of males during primary infection might decrease HIV-1 transmission in human populations and therefore affect the spread of AIDS.",

author = "Whitney, {James B.} and Corinne Luedemann and Peter Hraber and Rao, {Srinivas S.} and Mascola, {John R.} and Nabel, {Gary J.} and Letvin, {Norman L.}",

year = "2009",

month = oct,

doi = "10.1128/JVI.01202-09",

language = "English (US)",

volume = "83",

pages = "10840--10843",

journal = "Journal of Virology",

issn = "0022-538X",

publisher = "American Society for Microbiology",

number = "20",

}

TY - JOUR

T1 - T-cell vaccination reduces simian immunodeficiency virus levels in semen

AU - Whitney, James B.

AU - Luedemann, Corinne

AU - Hraber, Peter

AU - Rao, Srinivas S.

AU - Mascola, John R.

AU - Nabel, Gary J.

AU - Letvin, Norman L.

PY - 2009/10

Y1 - 2009/10

N2 - Recent findings suggest that most sexual transmission of human immunodeficiency virus type 1 (HIV-1) occurs during the acute phase of infection when viral replication is most intense. Here, we show that vaccineelicited cellular immune responses can significantly reduce simian immunodeficiency virus levels in the semen during the period of primary infection in monkeys. A vaccine that decreases the quantity of HIV-1 in the semen of males during primary infection might decrease HIV-1 transmission in human populations and therefore affect the spread of AIDS.

AB - Recent findings suggest that most sexual transmission of human immunodeficiency virus type 1 (HIV-1) occurs during the acute phase of infection when viral replication is most intense. Here, we show that vaccineelicited cellular immune responses can significantly reduce simian immunodeficiency virus levels in the semen during the period of primary infection in monkeys. A vaccine that decreases the quantity of HIV-1 in the semen of males during primary infection might decrease HIV-1 transmission in human populations and therefore affect the spread of AIDS.

UR - http://www.scopus.com/inward/record.url?scp=70349970517&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349970517&partnerID=8YFLogxK

U2 - 10.1128/JVI.01202-09

DO - 10.1128/JVI.01202-09

M3 - Article

C2 - 19640980

AN - SCOPUS:70349970517

VL - 83

SP - 10840

EP - 10843

JO - Journal of Virology

JF - Journal of Virology

SN - 0022-538X

IS - 20

ER -

T-cell vaccination reduces simian immunodeficiency virus levels in semen

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this