T-cell vaccination reduces simian immunodeficiency virus levels in semen

James B. Whitney; Corinne Luedemann; Peter Hraber; Srinivas S. Rao; John R. Mascola; Gary J. Nabel; Norman L. Letvin

doi:10.1128/JVI.01202-09

T-cell vaccination reduces simian immunodeficiency virus levels in semen

James B. Whitney, Corinne Luedemann, Peter Hraber, Srinivas S. Rao, John R. Mascola, Gary J. Nabel, Norman L. Letvin

Research output: Contribution to journal › Article › peer-review

Abstract

Recent findings suggest that most sexual transmission of human immunodeficiency virus type 1 (HIV-1) occurs during the acute phase of infection when viral replication is most intense. Here, we show that vaccineelicited cellular immune responses can significantly reduce simian immunodeficiency virus levels in the semen during the period of primary infection in monkeys. A vaccine that decreases the quantity of HIV-1 in the semen of males during primary infection might decrease HIV-1 transmission in human populations and therefore affect the spread of AIDS.

Original language	English (US)
Pages (from-to)	10840-10843
Number of pages	4
Journal	Journal of virology
Volume	83
Issue number	20
DOIs	https://doi.org/10.1128/JVI.01202-09
State	Published - Oct 2009
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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10.1128/JVI.01202-09

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AU - Hraber, Peter

AU - Rao, Srinivas S.

AU - Mascola, John R.

AU - Nabel, Gary J.

AU - Letvin, Norman L.

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AB - Recent findings suggest that most sexual transmission of human immunodeficiency virus type 1 (HIV-1) occurs during the acute phase of infection when viral replication is most intense. Here, we show that vaccineelicited cellular immune responses can significantly reduce simian immunodeficiency virus levels in the semen during the period of primary infection in monkeys. A vaccine that decreases the quantity of HIV-1 in the semen of males during primary infection might decrease HIV-1 transmission in human populations and therefore affect the spread of AIDS.

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T-cell vaccination reduces simian immunodeficiency virus levels in semen

Abstract

ASJC Scopus subject areas

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