T-cell vaccination reduces simian immunodeficiency virus levels in semen

James B. Whitney, Corinne Luedemann, Peter Hraber, Srinivas S. Rao, John R. Mascola, Gary J. Nabel, Norman L. Letvin

Research output: Contribution to journalArticle

Abstract

Recent findings suggest that most sexual transmission of human immunodeficiency virus type 1 (HIV-1) occurs during the acute phase of infection when viral replication is most intense. Here, we show that vaccineelicited cellular immune responses can significantly reduce simian immunodeficiency virus levels in the semen during the period of primary infection in monkeys. A vaccine that decreases the quantity of HIV-1 in the semen of males during primary infection might decrease HIV-1 transmission in human populations and therefore affect the spread of AIDS.

Original languageEnglish (US)
Pages (from-to)10840-10843
Number of pages4
JournalJournal of virology
Volume83
Issue number20
DOIs
StatePublished - Oct 1 2009

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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  • Cite this

    Whitney, J. B., Luedemann, C., Hraber, P., Rao, S. S., Mascola, J. R., Nabel, G. J., & Letvin, N. L. (2009). T-cell vaccination reduces simian immunodeficiency virus levels in semen. Journal of virology, 83(20), 10840-10843. https://doi.org/10.1128/JVI.01202-09