T cell-tropic HIV gp120 mediates CD4 and CD8 cell chemotaxis through CXCR4 independent of CD4: Implications for HIV pathogenesis

Sujatha Iyengar, David H. Schwartz, James E K Hildreth

    Research output: Contribution to journalArticlepeer-review

    Abstract

    HIV entry is determined by one or more chemokine receptors. T cell- tropic viruses bind CXCR4, whereas macrophage-tropic viruses use CCR5 and other CCRs. Infection with CXCR4 and CCR5-tropic HIV requires initial binding to CD4, and chemotaxis induced by the CCR5-tropic envelope has been reported to be strictly dependent on CD4 binding. We demonstrate that, in contrast to CD4-dependent gp120 signaling via CCR5, envelope signaling through CXCR4 is CD4 independent, inducing chemotaxis of both CD4 and CD8 T cells. Signaling by virus or soluble envelope through CXCR4 may affect pathogenesis by attracting and activating target and effector cells.

    Original languageEnglish (US)
    Pages (from-to)6263-6267
    Number of pages5
    JournalJournal of Immunology
    Volume162
    Issue number10
    StatePublished - May 15 1999

    ASJC Scopus subject areas

    • Immunology

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