T cell subsets and cytomegalovirus retinitis in human immunodeficiency virus-infected patients

Mei Ling Tay-Kearney, Cheryl Enger, Richard D. Semba, Walter Royal, James P. Dunn, Douglas A. Jabs

Research output: Contribution to journalArticle

Abstract

A case-control study was done to investigate the relationship between T cell subsets and cytomegalovirus (CMV) retinitis in human immunodeficiency virus (HIV)-infected subjects with or without CMV retinitis and CD4+ cell counts of <0.050 X 109/L. Cell surface markers on peripheral blood lymphocytes were evaluated using flow cytometry. Patients with CMV retinitis had significantly lower levels of CD8+ cells (median: 0.152 X 109/L) compared with levels for controls (median: 0.296 X 109/L, P < .001). Significant down-regulation of costimulatory molecule CD28+ and lymphocyte function-associated antigen-1 (LFA-1) expression was observed in patients versus controls (CD28+: 0.048 X 109/L vs. 0.143 X 109/L, P < .001; LFA-1: 0.238 x 109/L vs. 0.400 x 109/L, P < .001), but no significant differences were noted for NK cells. We propose that progressive loss of the CD3+ CD8+ cell subset and down-regulation of CD28 and LFA-1 accessory molecules are associated with an increased risk of CMV retinitis in HIV-infected patients.

Original languageEnglish (US)
Pages (from-to)790-794
Number of pages5
JournalJournal of Infectious Diseases
Volume176
Issue number3
DOIs
StatePublished - Jan 1 1997

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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