T cell response to 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNPase) in multiple sclerosis patients

P. A. Muraro, M. Kalbus, G. Afshar, H. F. McFarland, R. Martin

Research output: Contribution to journalArticlepeer-review

Abstract

T cell responses targeting myelin antigens are possibly involved in the pathogenesis of demyelinating diseases, such as multiple sclerosis (MS). Little is known about human T cell responses to 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNPase), the third most abundant myelin protein. We examined the primary peripheral T cell response to CNPase and characterized CNPase-specific CD4+ long-term T cell lines (TCL) from MS patients and healthy donors. The strongest primary responses were found in two MS patients with very active disease and were directed against CNP(343-373). We identified immunodominant epitope clusters in the regions CNP(343-373) and (356-388) that were recognized in the context of MS-associated HLA-DR2 and DR4 molecules. These data provide the immunological basis for further investigation of CNPase as a potential target self-antigen in MS.

Original languageEnglish (US)
Pages (from-to)233-242
Number of pages10
JournalJournal of Neuroimmunology
Volume130
Issue number1-2
DOIs
StatePublished - Sep 2002
Externally publishedYes

Keywords

  • 2′,3′-Cyclic nucleotide 3′-phosphodiesterase
  • Epitopes
  • Multiple sclerosis
  • Myelin proteins

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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