Abstract
T cell responses targeting myelin antigens are possibly involved in the pathogenesis of demyelinating diseases, such as multiple sclerosis (MS). Little is known about human T cell responses to 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNPase), the third most abundant myelin protein. We examined the primary peripheral T cell response to CNPase and characterized CNPase-specific CD4+ long-term T cell lines (TCL) from MS patients and healthy donors. The strongest primary responses were found in two MS patients with very active disease and were directed against CNP(343-373). We identified immunodominant epitope clusters in the regions CNP(343-373) and (356-388) that were recognized in the context of MS-associated HLA-DR2 and DR4 molecules. These data provide the immunological basis for further investigation of CNPase as a potential target self-antigen in MS.
Original language | English (US) |
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Pages (from-to) | 233-242 |
Number of pages | 10 |
Journal | Journal of Neuroimmunology |
Volume | 130 |
Issue number | 1-2 |
DOIs | |
State | Published - Sep 2002 |
Externally published | Yes |
Keywords
- 2′,3′-Cyclic nucleotide 3′-phosphodiesterase
- Epitopes
- Multiple sclerosis
- Myelin proteins
ASJC Scopus subject areas
- Immunology
- Clinical Neurology
- Immunology and Allergy
- Neurology